SCHEMBL3370471

SCHEMBL3370471

C/C=C1\C(=O)c2ccccc2C1(C)C

nearest known ligand 0.67

Predicted protein targets (top 20)

geneUniProtsupporting neighboursconfidence
PGR P06401 10/20 0.41
MEN1 O00255 4/20 0.37
KMT2A Q03164 4/20 0.37
PDK2 Q15119 1/20 0.37
PDK4 Q16654 1/20 0.37
MLNR O43193 1/20 0.37
NR1I2 O75469 1/20 0.37
CHRM2 P08172 1/20 0.37
ADRB1 P08588 1/20 0.37
HTR1A P08908 1/20 0.37
ADRA2A P08913 1/20 0.37
CHRM1 P11229 1/20 0.37
DRD2 P14416 1/20 0.37
ADRA2B P18089 1/20 0.37
ADRA2C P18825 1/20 0.37
CHRM3 P20309 1/20 0.37
DRD1 P21728 1/20 0.37
SLC6A2 P23975 1/20 0.37
HTR2A P28223 1/20 0.37
HTR2C P28335 1/20 0.37

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL3370477 1.00 PGR (0.41) PGRMEN1KMT2APDK2PDK4
SCHEMBL3369116 0.80 PGR (0.39) PGRMEN1KMT2APDK2PDK4
SCHEMBL11871293 0.80 HPGD (0.44) PGRMEN1KMT2ACYP1A2KDM4E
SCHEMBL11871299 0.80 HPGD (0.44) PGRMEN1KMT2ACYP1A2KDM4E
SCHEMBL16746500 0.80 HPGD (0.44) PGRMEN1KMT2ACYP1A2KDM4E
SCHEMBL3369111 0.80 PGR (0.39) PGRMEN1KMT2APDK2PDK4
SCHEMBL29522682 0.79 MEN1 (0.52) PGRMEN1KMT2APDK2PDK4
SCHEMBL12997896 0.79 MEN1 (0.52) PGRMEN1KMT2APDK2PDK4
SCHEMBL1855552 0.79 MEN1 (0.52) PGRMEN1KMT2APDK2PDK4
SCHEMBL12997894 0.79 MEN1 (0.52) PGRMEN1KMT2APDK2PDK4

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 5 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
EP-1478616-B1 INDANES AND INDANONES AND THEIR USE IN PERFUMERY GIVAUDAN SA (CH) 2010-09-22 EP disclosed
US-7538243-B2 Indanes and indanones and their use in perfumery GIVAUDAN SA (CH) 2009-05-26 US disclosed
CN-1329365-C Indanes and indanones and their use in perfumery GIVAUDAN SA (CH) 2007-08-01 CN disclosed
US-20050148493-A1 Indanes and indanones and their use in perfumery FLACHSMANN FELIX (CH) 2005-07-07 US disclosed
CN-1615294-A Indanes and indanones and their use in perfumery GIVAUDAN SA (CH) 2005-05-11 CN disclosed

Patent text — is the patent's own abstract consistent with the prediction?

For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.

PatentTitleText reads most aboutPredicted target · text-rank
US-20050148493-A1 Indanes and indanones and their use in perfumery NISCH, CYP1B1, CYP2E1 PGR 798/4885MEN1 4624/4885KMT2A 3789/4885

“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.