Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KDM4E | B2RXH2 | 3/20 | 0.50 |
| ▸ | DAO | P14920 | 2/20 | 0.50 |
| ▸ | MAPT | P10636 | 1/20 | 0.50 |
| ▸ | HPGD | P15428 | 1/20 | 0.50 |
| ▸ | SRD5A2 | P31213 | 1/20 | 0.50 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.50 |
| ▸ | FLT3 | P36888 | 4/20 | 0.47 |
| ▸ | LMNA | P02545 | 2/20 | 0.45 |
| ▸ | TP53 | P04637 | 1/20 | 0.45 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.45 |
| ▸ | NPC1 | O15118 | 2/20 | 0.43 |
| ▸ | RAB9A | P51151 | 2/20 | 0.43 |
| ▸ | IDO1 | P14902 | 1/20 | 0.43 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.43 |
| ▸ | DDO | Q99489 | 1/20 | 0.42 |
| ▸ | MAPK1 | P28482 | 2/20 | 0.41 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.41 |
| ▸ | GAA | P10253 | 1/20 | 0.41 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.40 |
| ▸ | PDGFRB | P09619 | 2/20 | 0.40 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL1833251 | 0.77 | KDM4E (0.55) | KDM4EDAOMAPTHPGDSRD5A2 | |
| SCHEMBL4278632 | 0.75 | KDM4E (0.50) | KDM4EDAOMAPTHPGDSRD5A2 | |
| SCHEMBL4013345 | 0.75 | KDM4E (0.39) | KDM4EDAOMAPTHPGDSRD5A2 | |
| SCHEMBL6586200 | 0.75 | KDM4E (0.50) | KDM4EDAOMAPTHPGDSRD5A2 | |
| Acetic Acid SCHEMBL29113245 | 0.75 | KDM4E (0.51) | KDM4EDAOMAPTHPGDSRD5A2 | |
| SCHEMBL6570396 | 0.74 | KDM4E (0.38) | KDM4EDAOMAPTHPGDSRD5A2 | |
| SCHEMBL10441468 | 0.73 | PDGFRB (0.58) | KDM4EDAOMAPTHPGDSRD5A2 | |
| SCHEMBL6470774 | 0.73 | FLT3 (0.47) | KDM4EDAOMAPTHPGDSRD5A2 | |
| SCHEMBL6146231 | 0.73 | KDM4E (0.38) | KDM4EDAOMAPTHPGDSRD5A2 | |
| SCHEMBL30073611 | 0.72 | PDGFRB (0.56) | KDM4EDAOMAPTHPGDSRD5A2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1757585-B1 | Anionically substituted 7-Nitroindoline derivatives and their uses | MEDICAL RES COUNCIL (GB) | 2010-12-01 | — | — | EP | disclosed |
| US-7737169-B2 | Anionically substituted 7-nitroindoline derivatives and their uses | MEDICAL RESEARCH COUNCIL (GB) | 2010-06-15 | — | — | US | disclosed |
| EP-1757585-A1 | Anionically substituted 7-Nitroindoline derivatives and their uses | Medical Research Council (GB) | 2007-02-28 | — | — | EP | disclosed |