Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KDM4E | B2RXH2 | 3/20 | 0.50 |
| ▸ | LMNA | P02545 | 2/20 | 0.50 |
| ▸ | TP53 | P04637 | 1/20 | 0.50 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.50 |
| ▸ | TAS1R3 | Q7RTX0 | 1/20 | 0.49 |
| ▸ | TAS1R1 | Q7RTX1 | 1/20 | 0.49 |
| ▸ | FLT3 | P36888 | 4/20 | 0.49 |
| ▸ | DRD2 | P14416 | 1/20 | 0.48 |
| ▸ | MTNR1A | P48039 | 1/20 | 0.48 |
| ▸ | MTNR1B | P49286 | 1/20 | 0.48 |
| ▸ | DAO | P14920 | 2/20 | 0.47 |
| ▸ | MAPT | P10636 | 1/20 | 0.47 |
| ▸ | HPGD | P15428 | 1/20 | 0.47 |
| ▸ | SRD5A2 | P31213 | 1/20 | 0.47 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.47 |
| ▸ | NPC1 | O15118 | 2/20 | 0.47 |
| ▸ | RAB9A | P51151 | 2/20 | 0.47 |
| ▸ | PDGFRB | P09619 | 4/20 | 0.47 |
| ▸ | PDGFRA | P16234 | 4/20 | 0.47 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.46 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL30073611 | 0.84 | PDGFRB (0.56) | KDM4ELMNATP53L3MBTL1FLT3 | |
| SCHEMBL4265956 | 0.84 | PDGFRB (0.56) | KDM4ELMNATP53L3MBTL1FLT3 | |
| SCHEMBL30344556 | 0.83 | ALDH1A1 (0.47) | KDM4ELMNATP53L3MBTL1TAS1R3 | |
| SCHEMBL29875229 | 0.83 | KDM4E (0.51) | KDM4ELMNATP53L3MBTL1TAS1R3 | |
| SCHEMBL1833251 | 0.82 | KDM4E (0.55) | KDM4ELMNATP53L3MBTL1FLT3 | |
| SCHEMBL5260106 | 0.82 | KDM4E (0.48) | KDM4ELMNATP53L3MBTL1TAS1R3 | |
| SCHEMBL29068747 | 0.82 | KDM4E (0.50) | KDM4ELMNATP53L3MBTL1TAS1R3 | |
| SCHEMBL6470774 | 0.81 | FLT3 (0.47) | KDM4ELMNATP53L3MBTL1TAS1R3 | |
| SCHEMBL10343383 | 0.81 | FLT3 (0.47) | KDM4ELMNATP53L3MBTL1FLT3 | |
| Hydrochloric Acid SCHEMBL6984470 | 0.81 | KDM4E (0.47) | KDM4ELMNATP53L3MBTL1TAS1R3 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1472221-A2 | SUBSTITUTED INDOLES, METHOD FOR PRODUCTION AND USE THEREOF FOR THE INHIBITION OF PAIN | Grünenthal GmbH (DE) | 2004-11-03 | — | — | EP | disclosed |
| WO-2003037863-A2 | SUBSTITUTED INDOLES, METHOD FOR PRODUCTION AND USE THEREOF FOR THE INHIBITION OF PAIN | Grünenthal GmbH (DE) | 2003-05-08 | — | — | WO | disclosed |