Predicted protein targets (top 14)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | GRM5 | P41594 | 7/20 | 0.47 |
| ▸ | AOC3 | Q16853 | 2/20 | 0.42 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.40 |
| ▸ | DPP4 | P27487 | 1/20 | 0.40 |
| ▸ | DPP8 | Q6V1X1 | 1/20 | 0.40 |
| ▸ | MAPK1 | P28482 | 4/20 | 0.39 |
| ▸ | HTR1A | P08908 | 1/20 | 0.38 |
| ▸ | DRD2 | P14416 | 1/20 | 0.38 |
| ▸ | HTR2A | P28223 | 1/20 | 0.38 |
| ▸ | GABRG2 | P18507 | 1/20 | 0.36 |
| ▸ | GABRB3 | P28472 | 1/20 | 0.36 |
| ▸ | GABRA5 | P31644 | 1/20 | 0.36 |
| ▸ | KCNH2 | Q12809 | 1/20 | 0.36 |
| ▸ | ALPL | P05186 | 1/20 | 0.36 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL23530026 | 0.82 | GRM5 (0.45) | GRM5AOC3CYP3A4DPP4DPP8 | |
| SCHEMBL3371568 | 0.82 | GRM5 (0.41) | GRM5 | |
| SCHEMBL10008685 | 0.79 | GAA (0.51) | — | |
| SCHEMBL3372611 | 0.78 | GRM5 (0.38) | GRM5 | |
| SCHEMBL3371217 | 0.77 | GRM5 (0.59) | GRM5GABRG2GABRB3GABRA5KCNH2 | |
| SCHEMBL22206984 | 0.77 | GRM5 (0.46) | GRM5AOC3CYP3A4DPP4DPP8 | |
| SCHEMBL3369525 | 0.76 | GRM5 (0.37) | GRM5 | |
| SCHEMBL3406745 | 0.76 | GRM5 (0.50) | GRM5MAPK1KCNH2 | |
| SCHEMBL3370931 | 0.76 | GRM5 (0.54) | GRM5KCNH2 | |
| SCHEMBL23530209 | 0.75 | GRM5 (0.41) | GRM5AOC3HTR1ADRD2HTR2A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2010052222-A1 | (DIHYDRO)NAPHTHYRIDINONE DERIVATIVES AS HISTAMINE H3 RECEPTOR ANTAGONISTS | EVOTEC NEUROSCIENCES GMBH (DE) | 2010-05-14 | — | — | WO | disclosed |
| WO-2010052222-A1 | (DIHYDRO)NAPHTHYRIDINONE DERIVATIVES AS HISTAMINE H3 RECEPTOR ANTAGONISTS | EVOTEC NEUROSCIENCES GMBH (DE) | 2010-05-14 | — | — | WO | disclosed |