Predicted protein targets (top 3)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | GRM5 | P41594 | 9/20 | 0.54 |
| ▸ | GRM2 | Q14416 | 8/20 | 0.43 |
| ▸ | KCNH2 | Q12809 | 6/20 | 0.43 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL3402683 | 0.93 | GRM5 (0.52) | GRM5GRM2KCNH2 | |
| SCHEMBL3370875 | 0.92 | GRM5 (0.47) | GRM5GRM2KCNH2 | |
| SCHEMBL3371568 | 0.81 | GRM5 (0.41) | GRM5 | |
| SCHEMBL3372611 | 0.78 | GRM5 (0.38) | GRM5 | |
| SCHEMBL3406745 | 0.78 | GRM5 (0.50) | GRM5GRM2KCNH2 | |
| SCHEMBL3370941 | 0.76 | GRM5 (0.47) | GRM5KCNH2 | |
| SCHEMBL3369525 | 0.76 | GRM5 (0.37) | GRM5 | |
| SCHEMBL3401858 | 0.76 | LMNA (0.49) | GRM5GRM2KCNH2 | |
| SCHEMBL22532086 | 0.75 | ACHE (0.43) | GRM5 | |
| SCHEMBL22216408 | 0.74 | GRM5 (0.46) | GRM5GRM2KCNH2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2010052222-A1 | (DIHYDRO)NAPHTHYRIDINONE DERIVATIVES AS HISTAMINE H3 RECEPTOR ANTAGONISTS | EVOTEC NEUROSCIENCES GMBH (DE) | 2010-05-14 | — | — | WO | disclosed |
| WO-2010052222-A1 | (DIHYDRO)NAPHTHYRIDINONE DERIVATIVES AS HISTAMINE H3 RECEPTOR ANTAGONISTS | EVOTEC NEUROSCIENCES GMBH (DE) | 2010-05-14 | — | — | WO | disclosed |