Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | GRM5 | P41594 | 3/20 | 0.50 |
| ▸ | DHPS | P49366 | 2/20 | 0.47 |
| ▸ | DDB1 | Q16531 | 1/20 | 0.46 |
| ▸ | CRBN | Q96SW2 | 1/20 | 0.46 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.44 |
| ▸ | L3MBTL1 | Q9Y468 | 2/20 | 0.43 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.43 |
| ▸ | LMNA | P02545 | 2/20 | 0.43 |
| ▸ | NCOA3 | Q9Y6Q9 | 1/20 | 0.43 |
| ▸ | KCNH2 | Q12809 | 1/20 | 0.40 |
| ▸ | GRM2 | Q14416 | 1/20 | 0.40 |
| ▸ | MEN1 | O00255 | 1/20 | 0.40 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.40 |
| ▸ | CLPP | Q16740 | 1/20 | 0.39 |
| ▸ | ACHE | P22303 | 1/20 | 0.39 |
| ▸ | PDE4A | P27815 | 1/20 | 0.39 |
| ▸ | PDE4B | Q07343 | 1/20 | 0.39 |
| ▸ | PDE4C | Q08493 | 1/20 | 0.39 |
| ▸ | PDE4D | Q08499 | 1/20 | 0.39 |
| ▸ | HTT | P42858 | 1/20 | 0.39 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL3401858 | 0.86 | LMNA (0.49) | GRM5L3MBTL1SMN1; SMN2LMNANCOA3 | |
| SCHEMBL20321441 | 0.85 | DHPS (0.49) | GRM5DHPSDDB1CRBNMAPK1 | |
| SCHEMBL10008685 | 0.83 | GAA (0.51) | SMN1; SMN2CLPP | |
| SCHEMBL3369476 | 0.82 | PTGDR2 (0.42) | GRM5KCNH2 | |
| SCHEMBL20321440 | 0.82 | GRM5 (0.46) | GRM5DHPSDDB1CRBNMAPK1 | |
| SCHEMBL3371418 | 0.81 | CHRM1 (0.43) | DHPSSMN1; SMN2LMNAGRM2MEN1 | |
| SCHEMBL3371568 | 0.81 | GRM5 (0.41) | GRM5MEN1KMT2AHTT | |
| SCHEMBL20321442 | 0.79 | GRM5 (0.46) | GRM5DHPSDDB1CRBNMAPK1 | |
| SCHEMBL31569013 | 0.79 | DHPS (0.57) | GRM5DHPSDDB1CRBNMAPK1 | |
| SCHEMBL5864164 | 0.78 | HTR1A (0.51) | GRM5DHPSDDB1CRBNL3MBTL1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2010052222-A1 | (DIHYDRO)NAPHTHYRIDINONE DERIVATIVES AS HISTAMINE H3 RECEPTOR ANTAGONISTS | EVOTEC NEUROSCIENCES GMBH (DE) | 2010-05-14 | — | — | WO | disclosed |
| WO-2010052222-A1 | (DIHYDRO)NAPHTHYRIDINONE DERIVATIVES AS HISTAMINE H3 RECEPTOR ANTAGONISTS | EVOTEC NEUROSCIENCES GMBH (DE) | 2010-05-14 | — | — | WO | disclosed |