Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | LTA4H | P09960 | 2/20 | 0.42 |
| ▸ | NPC1 | O15118 | 2/20 | 0.41 |
| ▸ | RAB9A | P51151 | 2/20 | 0.41 |
| ▸ | HPGD | P15428 | 1/20 | 0.41 |
| ▸ | CRHBP | P24387 | 1/20 | 0.41 |
| ▸ | CRHR2 | Q13324 | 1/20 | 0.41 |
| ▸ | HDAC3 | O15379 | 1/20 | 0.40 |
| ▸ | MTNR1A | P48039 | 2/20 | 0.40 |
| ▸ | MTNR1B | P49286 | 2/20 | 0.40 |
| ▸ | PTGS2 | P35354 | 2/20 | 0.39 |
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.39 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.39 |
| ▸ | LMNA | P02545 | 2/20 | 0.39 |
| ▸ | HTT | P42858 | 1/20 | 0.39 |
| ▸ | MAPT | P10636 | 1/20 | 0.39 |
| ▸ | THRB | P10828 | 1/20 | 0.39 |
| ▸ | ALOX5 | P09917 | 1/20 | 0.39 |
| ▸ | PPARG | P37231 | 1/20 | 0.39 |
| ▸ | PSEN1 | P49768 | 1/20 | 0.39 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.38 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL3368965 | 0.86 | NR1H4 (0.47) | NPC1RAB9AALDH1A1SMN1; SMN2LMNA | |
| SCHEMBL3368967 | 0.86 | NR1H4 (0.47) | NPC1RAB9AALDH1A1SMN1; SMN2LMNA | |
| SCHEMBL3368964 | 0.86 | NR1H4 (0.47) | NPC1RAB9AALDH1A1SMN1; SMN2LMNA | |
| SCHEMBL5384054 | 0.74 | PPARD (0.55) | LTA4HHDAC3PPARGHDAC8 | |
| SCHEMBL5384051 | 0.74 | PPARD (0.55) | LTA4HHDAC3PPARGHDAC8 | |
| SCHEMBL5607725 | 0.70 | NR1H4 (0.60) | NPC1RAB9AHDAC3ALDH1A1SMN1; SMN2 | |
| SCHEMBL5607721 | 0.70 | NR1H4 (0.60) | NPC1RAB9AHDAC3ALDH1A1SMN1; SMN2 | |
| SCHEMBL11426207 | 0.70 | KMT2A (0.48) | HPGDALDH1A1LMNAMAPTKDM4E | |
| SCHEMBL11426210 | 0.70 | KMT2A (0.48) | HPGDALDH1A1LMNAMAPTKDM4E | |
| Diphenylether SCHEMBL3558137 | 0.69 | LTA4H (0.62) | LTA4HNPC1RAB9AHPGDCRHBP |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1537091-B1 | NOVEL 2-ARYLTHIAZOLE COMPOUNDS AS PPARALPHA AND PPARGAMMA AGONISTS | HOFFMANN LA ROCHE (CH) | 2010-10-06 | — | — | EP | disclosed |