SCHEMBL337186

SCHEMBL337186

CC(C)(C)c1cccc(-n2nc3ccc(Cl)cc3n2)c1CO

nearest known ligand 0.34

Predicted protein targets (top 20)

geneUniProtsupporting neighboursconfidence
NPC1 O15118 3/20 0.34
RAB9A P51151 3/20 0.34
CNR2 P34972 1/20 0.34
KDM4E B2RXH2 4/20 0.33
MAPT P10636 4/20 0.33
ALDH1A1 P00352 3/20 0.33
HPGD P15428 3/20 0.33
KMT2A Q03164 3/20 0.33
MEN1 O00255 2/20 0.33
TP53 P04637 2/20 0.33
APAF1 O14727 1/20 0.33
ALOX15 P16050 1/20 0.33
CASP1 P29466 1/20 0.33
CASP7 P55210 1/20 0.33
HSD17B10 Q99714 1/20 0.33
ATM Q13315 1/20 0.33
CYP1A2 P05177 1/20 0.31
CYP2C9 P11712 1/20 0.31
CYP2C19 P33261 1/20 0.31
RXFP1 Q9HBX9 1/20 0.31

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL3664318 0.90 NPC1 (0.33) NPC1RAB9AKDM4EMAPTALDH1A1
SCHEMBL1767326 0.83 CA2 (0.42) NPC1RAB9AKDM4EMAPTALDH1A1
SCHEMBL30426108 0.83 CA2 (0.42) NPC1RAB9AKDM4EMAPTALDH1A1
Propanol SCHEMBL6572947 0.82 NPC1 (0.37) NPC1RAB9AKDM4EMAPTALDH1A1
SCHEMBL28393161 0.80 NPC1 (0.38) NPC1RAB9AKDM4EMAPTALDH1A1
Propionic Acid SCHEMBL2228683 0.78 NPC1 (0.36) NPC1RAB9ACNR2KDM4EMAPT
SCHEMBL2228686 0.76 MAPT (0.36) NPC1RAB9AKDM4EMAPTALDH1A1
SCHEMBL19752778 0.76 KDM4E (0.42) NPC1RAB9AKDM4EMAPTALDH1A1
SCHEMBL31252553 0.74 NPC1 (0.37) NPC1RAB9AKDM4EMAPTALDH1A1
SCHEMBL31419499 0.74 NPC1 (0.43) NPC1RAB9AKDM4EMAPTALDH1A1

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 5 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
US-8097190-B2 Optical resin composition having excellent impact resistance and method for fabricating optical lens using the same KOC SOLUTION CO., LTD. (KR) 2012-01-17 US disclosed
CN-101139430-B Optical resin composition having excellent impact resistance and method for fabricating optical lens using the same SHIN DAE SPECIALTIES CO LTD 2010-12-22 CN disclosed
US-20090225425-A1 OPTICAL RESIN COMPOSITION HAVING EXCELLENT IMPACT RESISTANCE AND METHOD FOR FABRICATING OPTICAL LENS USING THE SAME SHIN DAE SPECIALTIES CO., LTD. (KR) 2009-09-10 US disclosed
WO-2008029994-A1 OPTICAL RESIN COMPOSITION HAVING EXCELLENT IMPACT RESISTANCE AND METHOD FOR FABRICATING OPTICAL LENS USING THE SAME SHIN DAE SPECIALTIES CO., LTD. (KR) 2008-03-13 WO disclosed
US-5073583-A Peroxide curable; substituted benzo-triazole additive DOW CORNING CORPORATION (US) 1991-12-17 US disclosed