Predicted protein targets (top 17)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ALDH1A1 | P00352 | 7/20 | 0.60 |
| ▸ | MAPT | P10636 | 6/20 | 0.60 |
| ▸ | TSHR | P16473 | 6/20 | 0.60 |
| ▸ | MAPK1 | P28482 | 5/20 | 0.60 |
| ▸ | NPSR1 | Q6W5P4 | 3/20 | 0.60 |
| ▸ | HTT | P42858 | 3/20 | 0.59 |
| ▸ | LMNA | P02545 | 4/20 | 0.57 |
| ▸ | ALOX15 | P16050 | 1/20 | 0.57 |
| ▸ | PLD3 | Q8IV08 | 1/20 | 0.57 |
| ▸ | HSD17B10 | Q99714 | 2/20 | 0.56 |
| ▸ | BRAF | P15056 | 1/20 | 0.56 |
| ▸ | PIK3CG | P48736 | 1/20 | 0.56 |
| ▸ | SMN1; SMN2 | Q16637 | 4/20 | 0.55 |
| ▸ | TP53 | P04637 | 1/20 | 0.55 |
| ▸ | USP2 | O75604 | 1/20 | 0.54 |
| ▸ | PCSK9 | Q8NBP7 | 1/20 | 0.53 |
| ▸ | THRB | P10828 | 1/20 | 0.53 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL662570 | 0.90 | ALDH1A1 (0.62) | ALDH1A1MAPTTSHRMAPK1NPSR1 | |
| SCHEMBL16059173 | 0.90 | MAPT (0.58) | ALDH1A1MAPTTSHRMAPK1NPSR1 | |
| SCHEMBL16059115 | 0.81 | ALDH1A1 (0.53) | ALDH1A1MAPTTSHRMAPK1HTT | |
| SCHEMBL661150 | 0.81 | ALDH1A1 (0.74) | ALDH1A1MAPTTSHRMAPK1NPSR1 | |
| SCHEMBL28659797 | 0.81 | MAOB (0.56) | ALDH1A1MAPTTSHRMAPK1NPSR1 | |
| SCHEMBL661222 | 0.81 | ALDH1A1 (0.56) | ALDH1A1MAPTTSHRMAPK1NPSR1 | |
| SCHEMBL14238217 | 0.80 | ALDH1A1 (0.52) | ALDH1A1MAPTTSHRMAPK1NPSR1 | |
| SCHEMBL8243853 | 0.80 | ALDH1A1 (0.61) | ALDH1A1MAPTTSHRMAPK1NPSR1 | |
| SCHEMBL30361110 | 0.80 | ALDH1A1 (0.61) | ALDH1A1MAPTTSHRMAPK1NPSR1 | |
| SCHEMBL661185 | 0.80 | ALDH1A1 (0.61) | ALDH1A1MAPTTSHRMAPK1NPSR1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2010044878-A1 | METHODS AND COMPOSITIONS FOR IMPROVING COGNITIVE FUNCTION | THE JOHNS HOPKINS UNIVERSITY (US) | 2010-04-22 | — | — | WO | disclosed |
| EP-1963325-A2 | XANTHINE DERIVATIVES, PROCESSES FOR PREPARING THEM AND THEIR USES | UCB Pharma, S.A. (BE) | 2008-09-03 | — | — | EP | disclosed |
| WO-2007065595-A2 | XANTHINE DERIVATIVES, PROCESSES FOR PREPARING THEM AND THEIR USES | UCB PHARMA, S.A. (BE) | 2007-06-14 | — | — | WO | disclosed |