Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ALDH1A1 | P00352 | 10/20 | 0.74 |
| ▸ | HSD17B10 | Q99714 | 3/20 | 0.74 |
| ▸ | POLB | P06746 | 1/20 | 0.74 |
| ▸ | HPGD | P15428 | 1/20 | 0.74 |
| ▸ | HTT | P42858 | 3/20 | 0.61 |
| ▸ | LMNA | P02545 | 8/20 | 0.54 |
| ▸ | TSHR | P16473 | 8/20 | 0.54 |
| ▸ | SMN1; SMN2 | Q16637 | 7/20 | 0.54 |
| ▸ | MAPT | P10636 | 3/20 | 0.53 |
| ▸ | TP53 | P04637 | 1/20 | 0.53 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.53 |
| ▸ | MAPK1 | P28482 | 4/20 | 0.52 |
| ▸ | MAOA | P21397 | 1/20 | 0.52 |
| ▸ | MAOB | P27338 | 1/20 | 0.52 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.51 |
| ▸ | PKM | P14618 | 1/20 | 0.51 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.51 |
| ▸ | MEN1 | O00255 | 1/20 | 0.51 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.51 |
| ▸ | USP2 | O75604 | 1/20 | 0.51 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL662570 | 0.91 | ALDH1A1 (0.62) | ALDH1A1HSD17B10POLBHPGDHTT | |
| SCHEMBL8243853 | 0.83 | ALDH1A1 (0.61) | ALDH1A1HSD17B10POLBHPGDHTT | |
| SCHEMBL661185 | 0.83 | ALDH1A1 (0.61) | ALDH1A1HSD17B10POLBHPGDHTT | |
| SCHEMBL30361110 | 0.83 | ALDH1A1 (0.61) | ALDH1A1HSD17B10POLBHPGDHTT | |
| SCHEMBL661704 | 0.83 | ALDH1A1 (0.57) | ALDH1A1HSD17B10POLBHPGDHTT | |
| SCHEMBL28659797 | 0.82 | MAOB (0.56) | ALDH1A1HSD17B10POLBHPGDHTT | |
| SCHEMBL661222 | 0.82 | ALDH1A1 (0.56) | ALDH1A1HSD17B10POLBHPGDHTT | |
| SCHEMBL3372363 | 0.81 | ALDH1A1 (0.60) | ALDH1A1HSD17B10HTTLMNATSHR | |
| SCHEMBL661628 | 0.81 | ALDH1A1 (0.52) | ALDH1A1HSD17B10POLBHPGDHTT | |
| SCHEMBL8243849 | 0.80 | ALDH1A1 (0.60) | ALDH1A1HSD17B10POLBHPGDHTT |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 46 patents — showing the first 20. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20090018148-A1 | Xanthine Derivatives, Processes For Preparing Them And Their Uses | UCB PHARMA, S.A. (BE) | 2009-01-15 | — | — | US | claimed |
| EP-1963325-A2 | XANTHINE DERIVATIVES, PROCESSES FOR PREPARING THEM AND THEIR USES | UCB Pharma, S.A. (BE) | 2008-09-03 | — | — | EP | claimed |
| WO-2007065595-A2 | XANTHINE DERIVATIVES, PROCESSES FOR PREPARING THEM AND THEIR USES | UCB PHARMA, S.A. (BE) | 2007-06-14 | — | — | WO | claimed |
| US-20240293363-A1 | METHODS AND COMPOSITIONS FOR IMPROVING COGNITIVE FUNCTION | UNIV JOHNS HOPKINS (US) | 2024-09-05 | — | — | US | disclosed |
| US-20230277501-A1 | METHODS AND COMPOSITIONS FOR IMPROVING COGNITIVE FUNCTION | THE JOHNS HOPKINS UNIVERSITY | 2023-09-07 | — | — | US | disclosed |
| US-20230033195-A1 | METHODS AND COMPOSITIONS FOR IMPROVING COGNITIVE FUNCTION | THE JOHNS HOPKINS UNIVERSITY | 2023-02-02 | — | — | US | disclosed |
| US-20220265685-A1 | METHODS AND COMPOSITIONS FOR IMPROVING COGNITIVE FUNCTION | THE JOHNS HOPKINS UNIVERSITY | 2022-08-25 | — | — | US | disclosed |
| US-20220218665-A1 | METHODS AND COMPOSITIONS FOR IMPROVING COGNITIVE FUNCTION | UNIV JOHNS HOPKINS (US) | 2022-07-14 | — | — | US | disclosed |
| US-11160785-B2 | Methods and compositions for improving cognitive function | AGENEBIO INC. (US) | 2021-11-02 | — | — | US | disclosed |
| US-20210244709-A1 | METHODS AND COMPOSITIONS FOR IMPROVING COGNITIVE FUNCTION | THE JOHNS HOPKINS UNIVERSITY | 2021-08-12 | — | — | US | disclosed |
| EP-3827820-A1 | BRIVARACETAM FOR IMPROVING COGNITIVE FUNCTION | The Johns Hopkins University (US) | 2021-06-02 | — | — | EP | disclosed |
| US-20120214859-A1 | METHODS AND COMPOSITIONS FOR IMPROVING COGNITIVE FUNCTION | THE JOHNS HOPKINS UNIVERSITY | 2012-08-23 | — | — | US | disclosed |
| US-20120046336-A1 | METHODS AND COMPOSITIONS FOR IMPROVING COGNITIVE FUNCTION | THE JOHNS HOPKINS UNIVERSITY (US) | 2012-02-23 | — | — | US | disclosed |
| US-20110212928-A1 | METHODS AND COMPOSITIONS FOR IMPROVING COGNITIVE FUNCTION | THE JOHNS HOPKINS UNIVERSITY (US) | 2011-09-01 | — | — | US | disclosed |
| EP-2346500-A1 | METHODS AND COMPOSITIONS FOR IMPROVING COGNITIVE FUNCTION | The Johns Hopkins University (US) | 2011-07-27 | — | — | EP | disclosed |
| US-20100099735-A1 | METHODS AND COMPOSITIONS FOR IMPROVING COGNITIVE FUNCTION | NATIONAL INSTITUTES OF HEALTH - DIRECTOR DEITR | 2010-04-22 | — | — | US | disclosed |
| WO-2010044878-A1 | METHODS AND COMPOSITIONS FOR IMPROVING COGNITIVE FUNCTION | THE JOHNS HOPKINS UNIVERSITY (US) | 2010-04-22 | — | — | WO | disclosed |
| US-20090018148-A1 | Xanthine Derivatives, Processes For Preparing Them And Their Uses | UCB PHARMA, S.A. (BE) | 2009-01-15 | — | — | US | disclosed |
| EP-1963325-A2 | XANTHINE DERIVATIVES, PROCESSES FOR PREPARING THEM AND THEIR USES | UCB Pharma, S.A. (BE) | 2008-09-03 | — | — | EP | disclosed |
| WO-2007065595-A2 | XANTHINE DERIVATIVES, PROCESSES FOR PREPARING THEM AND THEIR USES | UCB PHARMA, S.A. (BE) | 2007-06-14 | — | — | WO | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (12 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20120046336-A1 | METHODS AND COMPOSITIONS FOR IMPROVING COGNITIVE FUNCTION | BACE2, RAB2A, VAMP8 | ALDH1A1 2819/4885HSD17B10 2745/4885POLB 4844/4885 |
| US-20210244709-A1 | METHODS AND COMPOSITIONS FOR IMPROVING COGNITIVE FUNCTION | GRIN2A, CHRNA2, SYNGR2 | ALDH1A1 2177/4885HSD17B10 929/4885POLB 4726/4885 |
| US-20090018148-A1 | Xanthine Derivatives, Processes For Preparing Them And Their Uses | XDH, HPRT1, UGT1A1 | ALDH1A1 243/4885HSD17B10 812/4885POLB 2407/4885 |
| US-11160785-B2 | Methods and compositions for improving cognitive function | BACE2, BACE1, GRIN2A | ALDH1A1 1226/4885HSD17B10 2514/4885POLB 2415/4885 |
| US-20100099735-A1 | METHODS AND COMPOSITIONS FOR IMPROVING COGNITIVE FUNCTION | BACE2, RAB2A, VAMP8 | ALDH1A1 2819/4885HSD17B10 2745/4885POLB 4844/4885 |
| US-20240293363-A1 | METHODS AND COMPOSITIONS FOR IMPROVING COGNITIVE FUNCTION | BACE2, RAB2A, VAMP8 | ALDH1A1 2819/4885HSD17B10 2745/4885POLB 4844/4885 |
| US-20120214859-A1 | METHODS AND COMPOSITIONS FOR IMPROVING COGNITIVE FUNCTION | GRIN2A, GRIN2D, SLC18A2 | ALDH1A1 1780/4885HSD17B10 1787/4885POLB 4535/4885 |
| US-20220218665-A1 | METHODS AND COMPOSITIONS FOR IMPROVING COGNITIVE FUNCTION | BACE2, RAB2A, VAMP8 | ALDH1A1 2819/4885HSD17B10 2745/4885POLB 4844/4885 |
| US-20230277501-A1 | METHODS AND COMPOSITIONS FOR IMPROVING COGNITIVE FUNCTION | GRIN2A, CHRNA2, SYNGR2 | ALDH1A1 2177/4885HSD17B10 929/4885POLB 4726/4885 |
| US-20220265685-A1 | METHODS AND COMPOSITIONS FOR IMPROVING COGNITIVE FUNCTION | BACE1, BACE2, ACHE | ALDH1A1 2614/4885HSD17B10 1998/4885POLB 2662/4885 |
| US-20110212928-A1 | METHODS AND COMPOSITIONS FOR IMPROVING COGNITIVE FUNCTION | BACE1, BACE2, ACHE | ALDH1A1 2614/4885HSD17B10 1998/4885POLB 2662/4885 |
| US-20230033195-A1 | METHODS AND COMPOSITIONS FOR IMPROVING COGNITIVE FUNCTION | GRIN2D, GRIN2A, SLC18A2 | ALDH1A1 2755/4885HSD17B10 1789/4885POLB 4585/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.