Predicted protein targets (top 6)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | REN | P00797 | 18/20 | 0.44 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.37 |
| ▸ | PDE4A | P27815 | 2/20 | 0.37 |
| ▸ | PDE4B | Q07343 | 2/20 | 0.37 |
| ▸ | PDE4C | Q08493 | 2/20 | 0.37 |
| ▸ | PDE4D | Q08499 | 2/20 | 0.37 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL8257452 | 0.89 | REN (0.52) | RENCYP3A4 | |
| SCHEMBL3372629 | 0.87 | REN (0.43) | RENCYP3A4 | |
| SCHEMBL2935467 | 0.83 | REN (0.51) | RENCYP3A4 | |
| SCHEMBL3374315 | 0.75 | REN (0.53) | RENCYP3A4 | |
| SCHEMBL3370509 | 0.74 | REN (0.43) | RENCYP3A4 | |
| SCHEMBL13068969 | 0.73 | REN (0.49) | REN | |
| SCHEMBL8260051 | 0.72 | REN (0.49) | REN | |
| SCHEMBL13068715 | 0.72 | REN (0.49) | REN | |
| SCHEMBL3370933 | 0.71 | REN (0.48) | REN | |
| SCHEMBL3369197 | 0.71 | REN (0.77) | RENCYP3A4 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1863477-B1 | 3,4-SUBSTITUTED PYRROLIDINE DERIVATIVES FOR THE TREATMENT OF HYPERTENSION | NOVARTIS AG (CH) | 2010-11-03 | — | — | EP | claimed |