Predicted protein targets (top 14)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | GRM4 | Q14833 | 5/20 | 0.36 |
| ▸ | GRM8 | O00222 | 3/20 | 0.36 |
| ▸ | GRM6 | O15303 | 2/20 | 0.36 |
| ▸ | GRM2 | Q14416 | 2/20 | 0.35 |
| ▸ | GRM5 | P41594 | 1/20 | 0.35 |
| ▸ | GRM1 | Q13255 | 1/20 | 0.35 |
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.34 |
| ▸ | MEN1 | O00255 | 1/20 | 0.34 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.34 |
| ▸ | TSHR | P16473 | 1/20 | 0.34 |
| ▸ | EPHX2 | P34913 | 1/20 | 0.33 |
| ▸ | ATM | Q13315 | 1/20 | 0.33 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.31 |
| ▸ | ARG1 | P05089 | 1/20 | 0.30 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL13757807 | 1.00 | GRM4 (0.36) | GRM4GRM8GRM6GRM2GRM5 | |
| Hydrochloric Acid SCHEMBL28747483 | 0.89 | EPHX2 (0.36) | GRM4GRM8GRM6GRM2GRM5 | |
| SCHEMBL3369422 | 0.84 | GRM2 (0.36) | GRM4GRM8GRM6GRM2GRM5 | |
| SCHEMBL3370713 | 0.84 | GRM2 (0.36) | GRM4GRM8GRM6GRM2GRM5 | |
| SCHEMBL13757783 | 0.84 | GRM2 (0.36) | GRM4GRM8GRM6GRM2GRM5 | |
| SCHEMBL13757812 | 0.84 | GRM2 (0.36) | GRM4GRM8GRM6GRM2GRM5 | |
| Hydrochloric Acid SCHEMBL28747513 | 0.83 | EPHX2 (0.35) | GRM2GRM5GRM1ALDH1A1TSHR | |
| Hydrochloric Acid SCHEMBL3375949 | 0.82 | GRM2 (0.35) | GRM4GRM8GRM6GRM2GRM5 | |
| SCHEMBL2738357 | 0.82 | GRM2 (0.35) | GRM4GRM8GRM6GRM2GRM5 | |
| SCHEMBL28747535 | 0.81 | ARG1 (0.35) | GRM4GRM8GRM6GRM2GRM5 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 6 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-8809267-B2 | Antiviral compounds | GILEAD SCIENCES, INC. (US) | 2014-08-19 | — | — | US | disclosed |
| US-20140051626-A1 | ANTIVIRAL COMPOUNDS | GILEAD SCIENCES, INC. (US) | 2014-02-20 | — | — | US | disclosed |
| US-8513186-B2 | Antiviral compounds | GILEAD SCIENCES, INC. (US) | 2013-08-20 | — | — | US | disclosed |
| EP-2162432-A2 | ANTIVIRAL COMPOUNDS | Gilead Sciences, Inc. (US) | 2010-03-17 | — | — | EP | disclosed |
| US-20090186869-A1 | Antiviral compounds | GILEAD SCIENCES, INC. (US) | 2009-07-23 | — | — | US | disclosed |
| WO-2009005677-A2 | ANTIVIRAL COMPOUNDS | GILEAD SCIENCES, INC. (US) | 2009-01-08 | — | — | WO | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (2 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20090186869-A1 | Antiviral compounds | MAVS, EIF2AK2, ZC3HAV1 | GRM4 3870/4885GRM8 4026/4885GRM6 3534/4885 |
| US-20140051626-A1 | ANTIVIRAL COMPOUNDS | MAVS, EIF2AK2, ZC3HAV1 | GRM4 3870/4885GRM8 4026/4885GRM6 3534/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.