Predicted protein targets (top 19)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | SMN1; SMN2 | Q16637 | 3/20 | 0.40 |
| ▸ | LMNA | P02545 | 2/20 | 0.40 |
| ▸ | DPP4 | P27487 | 1/20 | 0.38 |
| ▸ | KDM1A | O60341 | 1/20 | 0.38 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.35 |
| ▸ | GAA | P10253 | 2/20 | 0.35 |
| ▸ | MAPT | P10636 | 1/20 | 0.35 |
| ▸ | ATM | Q13315 | 1/20 | 0.35 |
| ▸ | TDP1 | Q9NUW8 | 2/20 | 0.35 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.35 |
| ▸ | MEN1 | O00255 | 1/20 | 0.35 |
| ▸ | POLB | P06746 | 1/20 | 0.35 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.35 |
| ▸ | ALOX12 | P18054 | 1/20 | 0.35 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.34 |
| ▸ | TSHR | P16473 | 1/20 | 0.34 |
| ▸ | L3MBTL1 | Q9Y468 | 2/20 | 0.34 |
| ▸ | HTT | P42858 | 1/20 | 0.34 |
| ▸ | RAB9A | P51151 | 1/20 | 0.34 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL445460 | 0.78 | SMN1; SMN2 (0.44) | SMN1; SMN2LMNAKDM1AKDM4EGAA | |
| SCHEMBL23012554 | 0.77 | SMN1; SMN2 (0.50) | SMN1; SMN2LMNAKDM1AKDM4EGAA | |
| SCHEMBL5718211 | 0.75 | SMN1; SMN2 (0.48) | SMN1; SMN2LMNAKDM1AKDM4EGAA | |
| SCHEMBL5178813 | 0.75 | SMN1; SMN2 (0.53) | SMN1; SMN2LMNAKDM1AKDM4EGAA | |
| SCHEMBL1622556 | 0.74 | KDM4E (0.58) | SMN1; SMN2LMNAKDM1AKDM4EGAA | |
| SCHEMBL22497146 | 0.74 | SMN1; SMN2 (0.47) | SMN1; SMN2LMNAKDM1AKDM4EGAA | |
| SCHEMBL28121427 | 0.72 | KDM4E (0.56) | SMN1; SMN2LMNAKDM1AKDM4EGAA | |
| SCHEMBL19459421 | 0.71 | SMN1; SMN2 (0.44) | SMN1; SMN2LMNAKDM1AKDM4EGAA | |
| SCHEMBL2445884 | 0.71 | ALDH1A1 (0.46) | SMN1; SMN2KDM4EMAPTATMTDP1 | |
| SCHEMBL16986510 | 0.71 | KMT2A (0.45) | SMN1; SMN2LMNAKDM4EMAPTATM |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2188256-A1 | RENIN INHIBITORS | Merck Frosst Canada Ltd. (CA) | 2010-05-26 | — | — | EP | disclosed |
| WO-2009018662-A9 | RENIN INHIBITORS | MERCK FROSST CANADA LTD. (CA) | 2010-04-08 | — | — | WO | disclosed |
| WO-2009018662-A1 | RENIN INHIBITORS | MERCK FROSST CANADA LTD. (CA) | 2009-02-12 | — | — | WO | disclosed |