Predicted protein targets (top 6)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PDE4A | P27815 | 18/20 | 0.50 |
| ▸ | PDE4B | Q07343 | 15/20 | 0.49 |
| ▸ | PDE4C | Q08493 | 15/20 | 0.49 |
| ▸ | PDE4D | Q08499 | 15/20 | 0.49 |
| ▸ | S1PR1 | P21453 | 1/20 | 0.43 |
| ▸ | S1PR3 | Q99500 | 1/20 | 0.43 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL3375194 | 0.95 | PDE4A (0.56) | PDE4APDE4BPDE4CPDE4DS1PR1 | |
| SCHEMBL3377465 | 0.82 | PDE4D (0.46) | PDE4APDE4BPDE4CPDE4D | |
| SCHEMBL3373175 | 0.80 | PDE4D (0.50) | PDE4APDE4BPDE4CPDE4D | |
| SCHEMBL3374189 | 0.79 | PDE4B (0.58) | PDE4APDE4BPDE4CPDE4D | |
| SCHEMBL3374953 | 0.76 | PDE4B (0.48) | PDE4APDE4BPDE4CPDE4D | |
| SCHEMBL5823060 | 0.74 | PDE4A (0.77) | PDE4APDE4BPDE4CPDE4DS1PR1 | |
| SCHEMBL28187722 | 0.73 | PDE4A (0.55) | PDE4APDE4BPDE4CPDE4DS1PR1 | |
| SCHEMBL3373532 | 0.73 | MAPT (0.69) | PDE4APDE4BPDE4CPDE4D | |
| SCHEMBL6919617 | 0.71 | PDE4A (0.59) | PDE4APDE4BPDE4CPDE4D | |
| SCHEMBL7364691 | 0.71 | PDE4A (0.59) | PDE4APDE4BPDE4CPDE4D |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20100324091-A1 | Pyrazolone Derivative | KOWA COMPANY, LTD. (JP) | 2010-12-23 | — | — | US | disclosed |
| EP-2172458-A1 | PYRAZOLONE DERIVATIVE | Kowa Company, Ltd. (JP) | 2010-04-07 | — | — | EP | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20100324091-A1 | Pyrazolone Derivative | SERPINE1, SERPINC1, TFPI | PDE4A 1796/4885PDE4B 1700/4885PDE4C 2308/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.