Predicted protein targets (top 3)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PTGDR2 | Q9Y5Y4 | 19/20 | 0.76 |
| ▸ | AKR1B1 | P15121 | 6/20 | 0.58 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.54 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL3373845 | 0.87 | PTGDR2 (0.76) | PTGDR2AKR1B1CYP2C9 | |
| SCHEMBL2049959 | 0.86 | PTGDR2 (1.00) | PTGDR2AKR1B1CYP2C9 | |
| SCHEMBL3372721 | 0.84 | PTGDR2 (0.79) | PTGDR2AKR1B1CYP2C9 | |
| SCHEMBL3372368 | 0.82 | PTGDR2 (0.76) | PTGDR2AKR1B1CYP2C9 | |
| SCHEMBL3371449 | 0.82 | PTGDR2 (0.78) | PTGDR2AKR1B1CYP2C9 | |
| SCHEMBL3371546 | 0.82 | PTGDR2 (0.74) | PTGDR2AKR1B1CYP2C9 | |
| SCHEMBL3368177 | 0.82 | PTGDR2 (1.00) | PTGDR2AKR1B1CYP2C9 | |
| SCHEMBL27990100 | 0.81 | PTGDR2 (0.73) | PTGDR2AKR1B1CYP2C9 | |
| SCHEMBL3405996 | 0.81 | PTGDR2 (0.73) | PTGDR2AKR1B1CYP2C9 | |
| SCHEMBL2052563 | 0.80 | PTGDR2 (0.71) | PTGDR2AKR1B1CYP2C9 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1656347-B1 | SUBSTITUTED INDOLE DERIVATIVES FOR PHARMACEUTICAL COMPOSITION FOR TREATING RESPIRATORY DISEASES | ASTRAZENECA AB (SE) | 2010-10-13 | — | — | EP | disclosed |
| US-7709521-B2 | Substituted indole derivatives for pharmaceutical compositions for treating respiratory diseases | ASTRAZENECA AB (SE) | 2010-05-04 | — | — | US | disclosed |
| US-20060264444-A1 | Substituted indole derivatives for pharmaceutical compositions for treating respiratory diseases | ASTRAZENECA AB (SE) | 2006-11-23 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20060264444-A1 | Substituted indole derivatives for pharmaceutical compositions for treating respiratory diseases | IDO1, IDO2, TPH1 | PTGDR2 303/4885AKR1B1 296/4885CYP2C9 178/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.