Predicted protein targets (top 16)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MAPT | P10636 | 1/20 | 0.44 |
| ▸ | TSHR | P16473 | 2/20 | 0.43 |
| ▸ | HTT | P42858 | 1/20 | 0.43 |
| ▸ | EGFR | P00533 | 2/20 | 0.41 |
| ▸ | PPARD | Q03181 | 1/20 | 0.38 |
| ▸ | TP53 | P04637 | 1/20 | 0.33 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.33 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.32 |
| ▸ | CCNT1 | O60563 | 1/20 | 0.32 |
| ▸ | CDK9 | P50750 | 1/20 | 0.32 |
| ▸ | POLB | P06746 | 2/20 | 0.32 |
| ▸ | MEN1 | O00255 | 1/20 | 0.32 |
| ▸ | GAA | P10253 | 1/20 | 0.32 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.32 |
| ▸ | KCNH2 | Q12809 | 1/20 | 0.32 |
| ▸ | LMNA | P02545 | 1/20 | 0.31 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL10022793 | 0.92 | MAPT (0.44) | MAPTTSHRHTTEGFRPPARD | |
| SCHEMBL4419535 | 0.91 | MAPT (0.42) | MAPTTSHRHTTEGFRPPARD | |
| SCHEMBL23908226 | 0.83 | TSHR (0.50) | MAPTTSHRHTTEGFRPPARD | |
| SCHEMBL3373657 | 0.83 | EGFR (0.39) | MAPTTSHRHTTEGFRCCNT1 | |
| SCHEMBL28823204 | 0.81 | EGFR (0.39) | MAPTTSHRHTTEGFRCCNT1 | |
| SCHEMBL7847174 | 0.81 | EGFR (0.39) | MAPTTSHRHTTEGFRTDP1 | |
| SCHEMBL18304415 | 0.81 | PYCR1 (0.39) | MAPTTSHRHTTEGFRTDP1 | |
| SCHEMBL31744500 | 0.81 | PPARD (0.44) | MAPTTSHRHTTPPARD | |
| SCHEMBL30626563 | 0.80 | MAPT (0.39) | MAPTTSHRHTTEGFRPPARD | |
| SCHEMBL24357401 | 0.80 | MAPT (0.39) | MAPTTSHRHTTEGFRPPARD |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 13 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2046785-B1 | 1,4-BIS(2-THIENYLVINYL)BENZOL DERIVATIVES AND THEIR USE | MERCK PATENT GMBH (DE) | 2013-02-27 | — | — | EP | disclosed |
| US-8236968-B2 | 1,4-bis(2-thienylvinyl)benzol derivatives and their use | MERCK PATENT GMBH (DE) | 2012-08-07 | — | — | US | disclosed |
| US-8236968-B2 | 1,4-bis(2-thienylvinyl)benzol derivatives and their use | MERCK PATENT GMBH (DE) | 2012-08-07 | — | — | US | disclosed |
| EP-2236488-A1 | Materials, methods and uses for photochemical generation of acids and/or radical species | The Arizona Board of Regents on behalf of the University of Arizona (US) | 2010-10-06 | — | — | EP | disclosed |
| US-20090321686-A1 | 1,4-BIS(2-THIENYLVINYL)BENZOL DERIVATIVES AND THEIR USE | BUESING ARNE | 2009-12-31 | — | — | US | disclosed |
| US-20090321686-A1 | 1,4-BIS(2-THIENYLVINYL)BENZOL DERIVATIVES AND THEIR USE | BUESING ARNE | 2009-12-31 | — | — | US | disclosed |
| EP-2046785-A1 | 1,4-BIS(2-THIENYLVINYL)BENZOL DERIVATIVES AND THEIR USE | Merck Patent GmbH (DE) | 2009-04-15 | — | — | EP | disclosed |
| US-7459106-B2 | Materials, methods, and uses for photochemical generation of acids and/or radical species | THE ARIZONA BOARD OF REGENTS ON BEHALF OF THE UNIVERSITY OF ARIZONA (US) | 2008-12-02 | — | — | US | disclosed |
| WO-2008011967-A1 | 1,4-BIS(2-THIENYLVINYL)BENZOL DERIVATIVES AND THEIR USE | MERCK PATENT GMBH (DE) | 2008-01-31 | — | — | WO | disclosed |
| EP-1390664-A4 | MATERIALS, METHODS, AND USES FOR PHOTOCHEMICAL GENERATION OF ACIDS AND/OR RADICAL SPECIES | UNIV ARIZONA (US) | 2008-01-02 | — | — | EP | disclosed |
| US-20050173683-A1 | Materials, methods, and uses for photochemical generation of acids and/or radical species | THE ARIZ BD OF REGENTS ON BEHALF OF THE UNIV OF AZ (US) | 2005-08-11 | — | — | US | disclosed |
| EP-1390664-A1 | MATERIALS, METHODS, AND USES FOR PHOTOCHEMICAL GENERATION OF ACIDS AND/OR RADICAL SPECIES | The Arizona Board of Regents (US) | 2004-02-25 | — | — | EP | disclosed |
| WO-2002079691-A1 | MATERIALS, METHODS, AND USES FOR PHOTOCHEMICAL GENERATION OF ACIDS AND/OR RADICAL SPECIES | THE ARIZONA BOARD OF REGENTS ON BEHALF OF THE UNIVERSITY OF ARIZONA (US) | 2002-10-10 | — | — | WO | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20090321686-A1 | 1,4-BIS(2-THIENYLVINYL)BENZOL DERIVATIVES AND THEIR USE | TTL, VCL, BRD4 | MAPT 854/4885TSHR 3265/4885HTT 1520/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.