SCHEMBL3373756

SCHEMBL3373756

CC(C)(C)OC(=O)N1CCC(OCc2ccc(-c3ccc(-n4cnnn4)cc3F)cc2)CC1

nearest known ligand 0.51

Predicted protein targets (top 2)

geneUniProtsupporting neighboursconfidence
GPR119 Q8TDV5 18/20 0.51
F11 P03951 2/20 0.40

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL13422383 0.89 GPR119 (0.53) GPR119
SCHEMBL3372317 0.87 GPR119 (0.50) GPR119
SCHEMBL3373458 0.81 GPR119 (0.56) GPR119
SCHEMBL13422591 0.80 SLC6A2 (0.39) GPR119
Hydrochloric Acid SCHEMBL3375634 0.79 SLC6A2 (0.38) GPR119
SCHEMBL3377912 0.79 GPR119 (0.47) GPR119
SCHEMBL3372327 0.78 GPR119 (0.49) GPR119
SCHEMBL14242773 0.77 GPR119 (0.47) GPR119F11
SCHEMBL4773784 0.77 GPR119 (0.64) GPR119
SCHEMBL3373094 0.76 SMN1; SMN2 (0.49) GPR119

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
WO-2010048149-A2 HETEROCYCLIC MODULATORS OF GPR119 FOR TREATMENT OF DISEASE KALYPSYS, INC. (US) 2010-04-29 WO disclosed
WO-2010048149-A2 HETEROCYCLIC MODULATORS OF GPR119 FOR TREATMENT OF DISEASE KALYPSYS, INC. (US) 2010-04-29 WO disclosed