Predicted protein targets (top 6)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | GPR119 | Q8TDV5 | 11/20 | 0.56 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.46 |
| ▸ | MAPT | P10636 | 2/20 | 0.44 |
| ▸ | TP53 | P04637 | 1/20 | 0.44 |
| ▸ | CHEK2 | O96017 | 1/20 | 0.43 |
| ▸ | PDE4D | Q08499 | 1/20 | 0.43 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL3372317 | 0.84 | GPR119 (0.50) | GPR119SMN1; SMN2MAPTTP53CHEK2 | |
| SCHEMBL11309424 | 0.83 | GPR119 (0.55) | GPR119 | |
| SCHEMBL3767188 | 0.83 | GPR119 (0.55) | GPR119 | |
| SCHEMBL3372121 | 0.81 | GPR119 (0.58) | GPR119SMN1; SMN2MAPTCHEK2 | |
| SCHEMBL3373756 | 0.81 | GPR119 (0.51) | GPR119 | |
| SCHEMBL3762480 | 0.80 | GPR119 (0.59) | GPR119 | |
| SCHEMBL10325161 | 0.80 | GPR119 (0.60) | GPR119 | |
| SCHEMBL4284717 | 0.80 | GPR119 (0.58) | GPR119 | |
| SCHEMBL1557229 | 0.80 | GPR119 (0.60) | GPR119 | |
| SCHEMBL3490335 | 0.79 | GPR119 (0.61) | GPR119SMN1; SMN2MAPT |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2010048149-A2 | HETEROCYCLIC MODULATORS OF GPR119 FOR TREATMENT OF DISEASE | KALYPSYS, INC. (US) | 2010-04-29 | — | — | WO | disclosed |
| WO-2010048149-A2 | HETEROCYCLIC MODULATORS OF GPR119 FOR TREATMENT OF DISEASE | KALYPSYS, INC. (US) | 2010-04-29 | — | — | WO | disclosed |