⚠ Novel chemotype — no close known analogue (best Tanimoto < 0.3). Unexplored chemical space relative to ChEMBL.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL5745619 | 0.77 | LMNA (0.30) | — | |
| SCHEMBL5745624 | 0.77 | LMNA (0.30) | — | |
| SCHEMBL8652409 | 0.74 | — | — | |
| SCHEMBL19638406 | 0.73 | LMNA (0.31) | — | |
| SCHEMBL2572609 | 0.71 | LMNA (0.30) | — | |
| SCHEMBL2572293 | 0.71 | LMNA (0.30) | — | |
| SCHEMBL26542416 | 0.68 | SMN1; SMN2 (0.31) | — | |
| SCHEMBL2574707 | 0.67 | — | — | |
| SCHEMBL6406821 | 0.65 | — | — | |
| SCHEMBL8677951 | 0.60 | — | — |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 10 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2287147-B1 | 2-Amino-bicyclo[3.1.0]hexane-2,6-dicarboxylic ester derivative | TAISHO PHARMACEUTICAL CO LTD (JP) | 2013-05-15 | — | — | EP | disclosed |
| EP-2123630-B1 | 2-Amino-bicyclo[3.1.0]hexane-2,6-dicarboxylic ester derivative | TAISHO PHARMACEUTICAL CO LTD (JP) | 2012-07-25 | — | — | EP | disclosed |
| EP-1637517-B1 | 2-AMINOBICYCLO 3.1.0 HEXANE-2,6-DICARBOXYLIC ESTER DERIVATIVE | TAISHO PHARMACEUTICAL CO LTD (JP) | 2010-11-10 | — | — | EP | disclosed |
| CN-1247527-C | 6-fluorobicyclo [3.1.0] hexane derivatives | TAISHO PHARMACEUTICAL CO LTD (JP) | 2006-03-29 | — | — | CN | disclosed |
| EP-1110943-B1 | 6-FLUOROBICYCLO 3. 1.0]HEXANE DERIVATIVES | TAISHO PHARMACEUTICAL CO LTD (JP) | 2004-06-16 | — | — | EP | disclosed |
| CN-1383423-A | 6-fluorobicyclo [3.1.0] hexame derivatives | TAISHO PHARMACEUTICAL CO LTD (JP) | 2002-12-04 | — | — | CN | disclosed |
| EP-1110943-A4 | 6-FLUOROBICYCLO 3. 1.0]HEXANE DERIVATIVES | TAISHO PHARMACEUTICAL CO LTD (JP) | 2002-07-10 | — | — | EP | disclosed |
| US-6333428-B1 | TREATMENT OR PREVENTION OF PSYCHIATRIC DISORDERS OR NEUROLOGICAL DISEASES | TAISHO PHARMACEUTICAL CO., LTD. (JP) | 2001-12-25 | — | — | US | disclosed |
| EP-1110943-A1 | 6-FLUOROBICYCLO 3. 1.0]HEXANE DERIVATIVES | Taisho Pharmaceutical Co. Ltd. (JP) | 2001-06-27 | — | — | EP | disclosed |
| WO-2000012464-A1 | 6-FLUOROBICYCLO[3. 1.0]HEXANE DERIVATIVES | TAISHO PHARMACEUTICAL CO., LTD. (JP) | 2000-03-09 | — | — | WO | disclosed |