Predicted protein targets (top 17)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | STK17A | Q9UEE5 | 7/20 | 0.43 |
| ▸ | STK17B | O94768 | 4/20 | 0.43 |
| ▸ | CSNK2A1 | P68400 | 1/20 | 0.39 |
| ▸ | JAK1 | P23458 | 3/20 | 0.38 |
| ▸ | BLK | P51451 | 3/20 | 0.38 |
| ▸ | JAK3 | P52333 | 3/20 | 0.38 |
| ▸ | TYRO3 | Q06418 | 2/20 | 0.38 |
| ▸ | MERTK | Q12866 | 2/20 | 0.38 |
| ▸ | AXL | P30530 | 1/20 | 0.38 |
| ▸ | BCL6 | P41182 | 2/20 | 0.38 |
| ▸ | TBK1 | Q9UHD2 | 3/20 | 0.38 |
| ▸ | JAK2 | O60674 | 2/20 | 0.38 |
| ▸ | FLT1 | P17948 | 2/20 | 0.38 |
| ▸ | FLT4 | P35916 | 2/20 | 0.38 |
| ▸ | ITK | Q08881 | 4/20 | 0.37 |
| ▸ | EGFR | P00533 | 2/20 | 0.37 |
| ▸ | SYK | P43405 | 1/20 | 0.36 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL3449898 | 0.90 | STK17A (0.42) | STK17ASTK17BCSNK2A1JAK1BLK | |
| SCHEMBL13312638 | 0.88 | STK17A (0.47) | STK17ASTK17BCSNK2A1JAK1BLK | |
| SCHEMBL13348200 | 0.81 | NPC1 (0.41) | JAK1JAK3TYRO3MERTKAXL | |
| SCHEMBL3449939 | 0.80 | STK17A (0.52) | STK17ASTK17BCSNK2A1JAK1BLK | |
| SCHEMBL3373032 | 0.80 | STK17A (0.47) | STK17ASTK17BCSNK2A1JAK1BLK | |
| SCHEMBL3449804 | 0.80 | STK17A (0.47) | STK17ASTK17BCSNK2A1JAK1BLK | |
| SCHEMBL13312642 | 0.80 | STK17A (0.46) | STK17ASTK17BCSNK2A1JAK1BLK | |
| SCHEMBL3449922 | 0.79 | STK17A (0.40) | STK17ASTK17BCSNK2A1JAK1BLK | |
| SCHEMBL3449539 | 0.79 | STK17A (0.48) | STK17ASTK17BCSNK2A1JAK1BLK | |
| SCHEMBL13312760 | 0.77 | STK17A (0.52) | STK17ASTK17BCSNK2A1JAK1BLK |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20100137313-A1 | HETEROCYCLIC DERIVATIVES AND METHODS OF USE THEREOF | ASTRAZENECA AB | 2010-06-03 | — | — | US | disclosed |
| US-20100137313-A1 | HETEROCYCLIC DERIVATIVES AND METHODS OF USE THEREOF | ASTRAZENECA AB | 2010-06-03 | — | — | US | disclosed |
| WO-2010038081-A2 | HETEROCYCLIC DERIVATIVES AND METHODS OF USE THEREOF | ASTRAZENECA AB (SE) | 2010-04-08 | — | — | WO | disclosed |
| WO-2010038081-A2 | HETEROCYCLIC DERIVATIVES AND METHODS OF USE THEREOF | ASTRAZENECA AB (SE) | 2010-04-08 | — | — | WO | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20100137313-A1 | HETEROCYCLIC DERIVATIVES AND METHODS OF USE THEREOF | SDHA, SDHB, UROD | STK17A 1984/4885STK17B 2457/4885CSNK2A1 1858/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.