Predicted protein targets (top 18)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KCNH2 | Q12809 | 2/20 | 0.44 |
| ▸ | ACVR1B | P36896 | 1/20 | 0.44 |
| ▸ | TGFBR1 | P36897 | 1/20 | 0.44 |
| ▸ | ACVR1 | Q04771 | 1/20 | 0.44 |
| ▸ | PRKCZ | Q05513 | 2/20 | 0.41 |
| ▸ | HRH3 | Q9Y5N1 | 2/20 | 0.41 |
| ▸ | IKBKB | O14920 | 3/20 | 0.37 |
| ▸ | HRH1 | P35367 | 3/20 | 0.37 |
| ▸ | ROCK1 | Q13464 | 3/20 | 0.35 |
| ▸ | CHUK | O15111 | 2/20 | 0.35 |
| ▸ | LCK | P06239 | 2/20 | 0.35 |
| ▸ | GRK6 | P43250 | 1/20 | 0.35 |
| ▸ | CHEK2 | O96017 | 1/20 | 0.35 |
| ▸ | KHK | P50053 | 1/20 | 0.35 |
| ▸ | DYRK1A | Q13627 | 3/20 | 0.35 |
| ▸ | WNT1 | P04628 | 2/20 | 0.35 |
| ▸ | GSK3B | P49841 | 2/20 | 0.35 |
| ▸ | KDM1A | O60341 | 1/20 | 0.34 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| Hydrochloric Acid SCHEMBL3371740 | 0.99 | KCNH2 (0.43) | KCNH2ACVR1BTGFBR1ACVR1PRKCZ | |
| SCHEMBL3374664 | 0.79 | GPR119 (0.48) | — | |
| SCHEMBL3375030 | 0.77 | GPR119 (0.40) | — | |
| SCHEMBL23410340 | 0.76 | HRH1 (0.49) | KCNH2ACVR1BTGFBR1ACVR1PRKCZ | |
| SCHEMBL3344194 | 0.72 | KCNH2 (0.45) | KCNH2ACVR1BTGFBR1ACVR1PRKCZ | |
| SCHEMBL18322870 | 0.68 | KCNH2 (0.45) | KCNH2ACVR1BTGFBR1ACVR1PRKCZ | |
| SCHEMBL2019376 | 0.67 | HRH1 (0.70) | KCNH2ACVR1BTGFBR1ACVR1PRKCZ | |
| Hydrochloric Acid SCHEMBL18318184 | 0.67 | KCNH2 (0.44) | KCNH2ACVR1BTGFBR1ACVR1PRKCZ | |
| SCHEMBL18318926 | 0.67 | PRKCZ (0.57) | KCNH2ACVR1BTGFBR1ACVR1PRKCZ | |
| SCHEMBL9264093 | 0.66 | GPR119 (0.40) | KCNH2PRKCZIKBKBROCK1CHUK |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2010048149-A2 | HETEROCYCLIC MODULATORS OF GPR119 FOR TREATMENT OF DISEASE | KALYPSYS, INC. (US) | 2010-04-29 | — | — | WO | disclosed |