Predicted protein targets (top 13)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.44 |
| ▸ | TP53 | P04637 | 2/20 | 0.43 |
| ▸ | MAPT | P10636 | 5/20 | 0.40 |
| ▸ | MEN1 | O00255 | 1/20 | 0.40 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.40 |
| ▸ | SCD | O00767 | 3/20 | 0.36 |
| ▸ | POLB | P06746 | 1/20 | 0.36 |
| ▸ | ADRB2 | P07550 | 1/20 | 0.36 |
| ▸ | GPR119 | Q8TDV5 | 5/20 | 0.36 |
| ▸ | KCNH2 | Q12809 | 1/20 | 0.35 |
| ▸ | USP2 | O75604 | 1/20 | 0.35 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.35 |
| ▸ | SCN9A | Q15858 | 1/20 | 0.34 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL3371752 | 0.86 | SMN1; SMN2 (0.44) | SMN1; SMN2TP53MAPTMEN1KMT2A | |
| SCHEMBL3376459 | 0.85 | TP53 (0.48) | SMN1; SMN2TP53MAPTMEN1KMT2A | |
| SCHEMBL13422781 | 0.82 | SMN1; SMN2 (0.45) | SMN1; SMN2TP53MAPTMEN1KMT2A | |
| SCHEMBL3374362 | 0.82 | GPR119 (0.52) | SMN1; SMN2TP53MAPTMEN1KMT2A | |
| SCHEMBL3374016 | 0.78 | SMN1; SMN2 (0.49) | SMN1; SMN2TP53MAPTMEN1KMT2A | |
| SCHEMBL13422305 | 0.78 | SMN1; SMN2 (0.48) | SMN1; SMN2TP53MAPTMEN1KMT2A | |
| Hydrochloric Acid SCHEMBL3370599 | 0.77 | SMN1; SMN2 (0.47) | SMN1; SMN2TP53MAPTMEN1KMT2A | |
| SCHEMBL3374622 | 0.77 | GPR119 (0.59) | SMN1; SMN2TP53MAPTMEN1KMT2A | |
| SCHEMBL3373094 | 0.73 | SMN1; SMN2 (0.49) | SMN1; SMN2TP53MAPTMEN1KMT2A | |
| SCHEMBL3372317 | 0.73 | GPR119 (0.50) | SMN1; SMN2TP53MAPTMEN1KMT2A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2010048149-A2 | HETEROCYCLIC MODULATORS OF GPR119 FOR TREATMENT OF DISEASE | KALYPSYS, INC. (US) | 2010-04-29 | — | — | WO | disclosed |
| WO-2010048149-A2 | HETEROCYCLIC MODULATORS OF GPR119 FOR TREATMENT OF DISEASE | KALYPSYS, INC. (US) | 2010-04-29 | — | — | WO | disclosed |