Predicted protein targets (top 18)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HRH3 | Q9Y5N1 | 1/20 | 0.38 |
| ▸ | KMT2A | Q03164 | 5/20 | 0.35 |
| ▸ | MEN1 | O00255 | 3/20 | 0.35 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.35 |
| ▸ | MAPT | P10636 | 1/20 | 0.35 |
| ▸ | ABL1 | P00519 | 1/20 | 0.33 |
| ▸ | ALPL | P05186 | 1/20 | 0.33 |
| ▸ | ALPI | P09923 | 1/20 | 0.33 |
| ▸ | ALPG | P10696 | 1/20 | 0.33 |
| ▸ | RIN1 | Q13671 | 1/20 | 0.33 |
| ▸ | P2RX7 | Q99572 | 1/20 | 0.32 |
| ▸ | GSK3B | P49841 | 1/20 | 0.32 |
| ▸ | DYRK1A | Q13627 | 1/20 | 0.32 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.32 |
| ▸ | POLB | P06746 | 1/20 | 0.32 |
| ▸ | LSS | P48449 | 1/20 | 0.31 |
| ▸ | ACACB | O00763 | 1/20 | 0.31 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.31 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL3380311 | 0.89 | HRH3 (0.39) | HRH3KMT2AMEN1ALDH1A1P2RX7 | |
| SCHEMBL3380414 | 0.85 | HRH3 (0.47) | HRH3KMT2AMEN1ALDH1A1MAPT | |
| SCHEMBL3380335 | 0.83 | HRH3 (0.39) | HRH3KMT2AMEN1ALDH1A1P2RX7 | |
| SCHEMBL3377338 | 0.82 | HRH3 (0.40) | HRH3KMT2AMEN1ALDH1A1P2RX7 | |
| SCHEMBL3376182 | 0.82 | HRH3 (0.45) | HRH3KMT2AMEN1ALDH1A1P2RX7 | |
| SCHEMBL3377269 | 0.82 | HRH3 (0.43) | HRH3KMT2AMEN1ALDH1A1P2RX7 | |
| SCHEMBL3381202 | 0.82 | HRH3 (0.39) | HRH3KMT2AMEN1ALDH1A1P2RX7 | |
| SCHEMBL3379864 | 0.81 | HRH3 (0.39) | HRH3KMT2AMEN1ALDH1A1MAPT | |
| SCHEMBL3378100 | 0.81 | HRH3 (0.40) | HRH3KMT2AMEN1ALDH1A1P2RX7 | |
| SCHEMBL3378211 | 0.81 | HRH3 (0.40) | HRH3KMT2AMEN1ALDH1A1P2RX7 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1899296-B1 | HISTAMINE-3 RECEPTOR ANTAGONISTS | PFIZER PROD INC (US) | 2010-11-17 | — | — | EP | claimed |