Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HRH3 | Q9Y5N1 | 4/20 | 0.47 |
| ▸ | FLT1 | P17948 | 2/20 | 0.36 |
| ▸ | FLT4 | P35916 | 2/20 | 0.36 |
| ▸ | KDR | P35968 | 2/20 | 0.36 |
| ▸ | MEN1 | O00255 | 2/20 | 0.34 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.34 |
| ▸ | HRH1 | P35367 | 2/20 | 0.34 |
| ▸ | CCR3 | P51677 | 2/20 | 0.34 |
| ▸ | KCNH2 | Q12809 | 2/20 | 0.34 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.34 |
| ▸ | MAPT | P10636 | 1/20 | 0.34 |
| ▸ | GSK3B | P49841 | 1/20 | 0.34 |
| ▸ | DYRK1A | Q13627 | 1/20 | 0.34 |
| ▸ | LSS | P48449 | 1/20 | 0.33 |
| ▸ | MLNR | O43193 | 1/20 | 0.33 |
| ▸ | ABL1 | P00519 | 1/20 | 0.32 |
| ▸ | ALPL | P05186 | 1/20 | 0.32 |
| ▸ | ALPI | P09923 | 1/20 | 0.32 |
| ▸ | ALPG | P10696 | 1/20 | 0.32 |
| ▸ | RIN1 | Q13671 | 1/20 | 0.32 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL3380899 | 0.85 | HRH3 (0.49) | HRH3FLT4MEN1KMT2AHRH1 | |
| SCHEMBL3375310 | 0.85 | HRH3 (0.38) | HRH3MEN1KMT2AALDH1A1MAPT | |
| SCHEMBL3377526 | 0.83 | HRH3 (0.47) | HRH3MEN1KMT2AHRH1CCR3 | |
| SCHEMBL3377768 | 0.83 | HRH3 (0.56) | HRH3MEN1KMT2AHRH1CCR3 | |
| SCHEMBL3380239 | 0.82 | HRH3 (0.54) | HRH3MEN1KMT2AHRH1CCR3 | |
| SCHEMBL3381646 | 0.82 | HRH3 (0.49) | HRH3FLT4KMT2AHRH1CCR3 | |
| SCHEMBL3377866 | 0.82 | HRH3 (0.48) | HRH3HRH1CCR3KCNH2ALDH1A1 | |
| SCHEMBL3414223 | 0.82 | HRH3 (0.48) | HRH3HRH1CCR3KCNH2MLNR | |
| SCHEMBL3377725 | 0.81 | HRH3 (0.46) | HRH3MEN1KMT2AHRH1CCR3 | |
| SCHEMBL3375063 | 0.81 | HRH3 (0.70) | HRH3HRH1CCR3KCNH2ALDH1A1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1899296-B1 | HISTAMINE-3 RECEPTOR ANTAGONISTS | PFIZER PROD INC (US) | 2010-11-17 | — | — | EP | claimed |