SCHEMBL3375342

SCHEMBL3375342

CC(C)(C)OC(=O)N[C@H]1C=CC[C@H]1C=O

nearest known ligand 0.43

Predicted protein targets (top 10)

geneUniProtsupporting neighboursconfidence
NFKB1 P19838 7/20 0.43
NFKB2 Q00653 7/20 0.43
RELA Q04206 7/20 0.43
BTK Q06187 1/20 0.36
GAA P10253 1/20 0.35
EPHX2 P34913 1/20 0.35
CTSK P43235 2/20 0.34
KDM1A O60341 2/20 0.34
MAPT P10636 1/20 0.34
MAOB P27338 1/20 0.33

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL3377157 0.83 NFKB1 (0.40) NFKB1NFKB2RELABTKGAA
SCHEMBL19497263 0.78 NFKB1 (0.45) NFKB1NFKB2RELABTKGAA
SCHEMBL29046653 0.77 BTK (0.47) NFKB1NFKB2RELABTKGAA
SCHEMBL29046655 0.77 BTK (0.47) NFKB1NFKB2RELABTKGAA
SCHEMBL3374188 0.72 NFKB1 (0.40) NFKB1NFKB2RELABTKGAA
SCHEMBL28039500 0.72 NFKB1 (0.40) NFKB1NFKB2RELABTKGAA
SCHEMBL28198523 0.72 NFKB1 (0.40) NFKB1NFKB2RELABTKGAA
SCHEMBL28199159 0.72 NFKB1 (0.40) NFKB1NFKB2RELABTKGAA
SCHEMBL4556862 0.72 BTK (0.44) NFKB1NFKB2RELABTKGAA
SCHEMBL3374919 0.72 NFKB1 (0.39) NFKB1NFKB2RELABTKGAA

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
WO-2012000608-A2 NOVEL BETA-AMINOALDEHYDE DERIVATIVES, PROCESS FOR THEIR PREPARATION AND THEIR CHEMICAL USE AS REACTIVE INTERMEDIATES GLUESENKAMP KARL-HEINZ (DE) 2012-01-05 WO disclosed