Predicted protein targets (top 14)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KMO | O15229 | 2/20 | 0.45 |
| ▸ | RPS6KB1 | P23443 | 17/20 | 0.42 |
| ▸ | AKT1 | P31749 | 13/20 | 0.42 |
| ▸ | AKT2 | P31751 | 2/20 | 0.42 |
| ▸ | KCNH2 | Q12809 | 2/20 | 0.42 |
| ▸ | AKT3 | Q9Y243 | 2/20 | 0.42 |
| ▸ | RPS6KA5 | O75582 | 2/20 | 0.41 |
| ▸ | RPS6KA4 | O75676 | 2/20 | 0.41 |
| ▸ | RPS6KA3 | P51812 | 2/20 | 0.41 |
| ▸ | RPS6KA2 | Q15349 | 2/20 | 0.41 |
| ▸ | RPS6KA1 | Q15418 | 2/20 | 0.41 |
| ▸ | RPS6KB2 | Q9UBS0 | 2/20 | 0.41 |
| ▸ | RPS6KA6 | Q9UK32 | 2/20 | 0.41 |
| ▸ | NOTUM | Q6P988 | 1/20 | 0.39 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL311583 | 0.86 | GPR119 (0.48) | — | |
| SCHEMBL19134021 | 0.85 | RPS6KB1 (0.41) | KMORPS6KB1AKT1AKT2KCNH2 | |
| SCHEMBL15732495 | 0.84 | P2RY14 (0.41) | KCNH2 | |
| SCHEMBL14782527 | 0.84 | TRPC3 (0.51) | — | |
| SCHEMBL6166219 | 0.83 | HTR2B (0.49) | KCNH2 | |
| SCHEMBL312676 | 0.82 | KMO (0.44) | KMORPS6KB1AKT1KCNH2 | |
| SCHEMBL311050 | 0.81 | MPL (0.44) | KMORPS6KB1AKT1RPS6KA5RPS6KA4 | |
| Hydrochloric Acid SCHEMBL310687 | 0.80 | MPL (0.43) | KMORPS6KB1AKT1RPS6KA5RPS6KA4 | |
| SCHEMBL6168951 | 0.79 | HTR2B (0.51) | — | |
| SCHEMBL6166669 | 0.78 | ABL1 (0.41) | — |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 6 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-102209538-B | Combination therapeutics of P70S 6 kinase inhibitors and EGFR inhibitors | LILLY CO ELI | 2013-06-12 | — | — | CN | disclosed |
| CN-102209539-B | Combination therapeutics of P70S 6 kinase inhibitors and MTOR inhibitors | LILLY CO ELI | 2013-06-12 | — | — | CN | disclosed |
| CN-102209538-A | Combination therapy of P70S 6 kinase inhibitors and EGFR inhibitors | LILLY CO ELI | 2011-10-05 | — | — | CN | disclosed |
| CN-102209539-A | Combination therapy of P70S 6 kinase inhibitors and MTOR inhibitors | LILLY CO ELI | 2011-10-05 | — | — | CN | disclosed |
| WO-2010056574-A1 | P70 S6 KINASE INHIBITOR AND MTOR INHIBITOR COMBINATION THERAPY | ELI LILLY AND COMPANY (US) | 2010-05-20 | — | — | WO | disclosed |
| WO-2010056575-A1 | P70 S6 KINASE INHIBITOR AND EGFR INHIBITOR COMBINATION THERAPY | ELI LILLY AND COMPANY (US) | 2010-05-20 | — | — | WO | disclosed |