Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HPGD | P15428 | 2/20 | 0.42 |
| ▸ | SMN1; SMN2 | Q16637 | 3/20 | 0.42 |
| ▸ | HRH3 | Q9Y5N1 | 1/20 | 0.42 |
| ▸ | ALDH1A1 | P00352 | 5/20 | 0.41 |
| ▸ | KDM4E | B2RXH2 | 3/20 | 0.41 |
| ▸ | NPSR1 | Q6W5P4 | 2/20 | 0.41 |
| ▸ | HSD17B10 | Q99714 | 2/20 | 0.41 |
| ▸ | GAA | P10253 | 2/20 | 0.41 |
| ▸ | USP2 | O75604 | 1/20 | 0.38 |
| ▸ | HTT | P42858 | 1/20 | 0.38 |
| ▸ | NCOA3 | Q9Y6Q9 | 1/20 | 0.38 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.38 |
| ▸ | MEN1 | O00255 | 1/20 | 0.38 |
| ▸ | TP53 | P04637 | 2/20 | 0.38 |
| ▸ | POLB | P06746 | 1/20 | 0.38 |
| ▸ | RBP4 | P02753 | 1/20 | 0.37 |
| ▸ | TSHR | P16473 | 1/20 | 0.37 |
| ▸ | NPC1 | O15118 | 1/20 | 0.37 |
| ▸ | RAB9A | P51151 | 1/20 | 0.37 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.37 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL3377374 | 0.91 | HRH3 (0.42) | HPGDSMN1; SMN2HRH3ALDH1A1KDM4E | |
| SCHEMBL3377289 | 0.85 | SMN1; SMN2 (0.44) | HPGDSMN1; SMN2HRH3ALDH1A1KDM4E | |
| SCHEMBL3379879 | 0.84 | HRH3 (0.41) | SMN1; SMN2HRH3ALDH1A1KDM4EHTT | |
| SCHEMBL3377941 | 0.83 | HRH3 (0.40) | SMN1; SMN2HRH3ALDH1A1KDM4EGAA | |
| SCHEMBL3376466 | 0.83 | ALDH1A1 (0.44) | SMN1; SMN2HRH3ALDH1A1KMT2AMEN1 | |
| SCHEMBL3377886 | 0.83 | KMT2A (0.41) | SMN1; SMN2HRH3ALDH1A1KDM4EKMT2A | |
| SCHEMBL3378180 | 0.82 | HRH3 (0.51) | HPGDSMN1; SMN2HRH3ALDH1A1KDM4E | |
| SCHEMBL3374944 | 0.81 | PKM (0.40) | HRH3ALDH1A1KDM4EHTTKMT2A | |
| SCHEMBL3376421 | 0.80 | HRH3 (0.44) | HRH3ALDH1A1KMT2AMEN1POLB | |
| SCHEMBL3377237 | 0.79 | HRH3 (0.41) | HRH3ALDH1A1KDM4EKMT2AMEN1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1899296-B1 | HISTAMINE-3 RECEPTOR ANTAGONISTS | PFIZER PROD INC (US) | 2010-11-17 | — | — | EP | disclosed |