SCHEMBL3376974

SCHEMBL3376974

CCCCCC(=S)O[Si](OCC)(OCC)OCC

nearest known ligand 0.33

Predicted protein targets (top 20)

geneUniProtsupporting neighboursconfidence
CES2 O00748 4/20 0.33
CES1 P23141 4/20 0.33
CA12 O43570 2/20 0.32
CA1 P00915 2/20 0.32
CA2 P00918 2/20 0.32
CA9 Q16790 2/20 0.32
HSP90AA1 P07900 1/20 0.32
AKR1B1 P15121 1/20 0.32
DGKA P23743 1/20 0.31
GPR84 Q9NQS5 7/20 0.31
PPARG P37231 6/20 0.31
PPARD Q03181 6/20 0.31
PPARA Q07869 6/20 0.31
HDAC11 Q96DB2 5/20 0.31
TSHR P16473 4/20 0.31
ALDH1A1 P00352 2/20 0.31
TLR2 O60603 2/20 0.31
TDP1 Q9NUW8 2/20 0.31
FABP4 P15090 2/20 0.31
PTPN1 P18031 2/20 0.31

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL4057647 0.85
SCHEMBL3374957 0.79
SCHEMBL2286399 0.76
SCHEMBL5178804 0.76 DGKA (0.48) CES2CES1HSP90AA1AKR1B1DGKA
SCHEMBL29168774 0.74 DGKA (0.52) CES2CES1HSP90AA1DGKAGPR84
SCHEMBL1517686 0.74 DGKA (0.52) CES2CES1HSP90AA1DGKAGPR84
SCHEMBL28286997 0.73 DGKA (0.50) CES2CES1HSP90AA1DGKAGPR84
SCHEMBL28293756 0.73 DGKA (0.50) CES2CES1HSP90AA1DGKAGPR84
Hexane SCHEMBL28732211 0.72 TSHR (0.44) TSHRALDH1A1MEN1KMT2AHSD17B10
SCHEMBL8744937 0.72 CA12 (0.43) CES2CES1CA12CA1CA2

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 173 patents — showing the first 20. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
EP-2978768-B1 CATALYTIC PROCESS FOR THE PREPARATION OF THIOCARBOXYLATE SILANE MOMENTIVE PERFORMANCE MAT INC (US) 2017-11-29 EP claimed
EP-1341843-B2 MINERAL-FILLED ELASTOMER COMPOSITIONS MOMENTIVE PERFORMANCE MAT INC (US) 2016-03-23 EP claimed
EP-1560836-B1 PROCESS FOR MANUFACTURE OF BLOCKED MERCAPTOSILANE COUPLING AGENTS MOMENTIVE PERFORMANCE MAT INC (US) 2015-12-30 EP claimed
EP-1669401-B1 Tire with tread containing combination of specialized elastomer and coupling agent GOODYEAR TIRE & RUBBER (US) 2013-07-31 EP claimed
EP-1491545-B1 Method of preparing a composite of hydrophobated amorphous silica employing blocked mercaptoalkoxysilanes GOODYEAR TIRE & RUBBER (US) 2009-01-14 EP claimed
EP-0958298-B2 BLOCKED MERCAPTOSILANE COUPLING AGENTS FOR FILLED RUBBERS MOMENTIVE PERFORMANCE MAT INC (US) 2008-10-22 EP claimed
EP-1341843-B1 MINERAL-FILLED ELASTOMER COMPOSITIONS GEN ELECTRIC (US) 2007-01-17 EP claimed
EP-0958298-B1 BLOCKED MERCAPTOSILANE COUPLING AGENTS FOR FILLED RUBBERS CROMPTON CORP (US) 2003-05-07 EP claimed
EP-0958298-A1 BLOCKED MERCAPTOSILANE COUPLING AGENTS FOR FILLED RUBBERS WITCO CORPORATION (US) 1999-11-24 EP claimed
WO-1999009036-A1 BLOCKED MERCAPTOSILANE COUPLING AGENTS FOR FILLED RUBBERS OSI SPECIALTIES, INC. (US) 1999-02-25 WO claimed
US-20240218165-A1 POLYMER-FILLER COMPOSITES WITH GUAYULE RUBBER BRIDGESTONE CORPORATION (JP) 2024-07-04 US disclosed
US-12006422-B2 Coupled polymer products, methods of making and compositions containing BRIDGESTONE CORPORATION (JP) 2024-06-11 US disclosed
US-20240117159-A1 Tire Having Tread Of Specified Rubber Composition And Related Methods BRIDGESTONE AMERICAS TIRE OPERATIONS, LLC 2024-04-11 US disclosed
US-20240110055-A1 RESIN-EXTENDED RUBBER AND PROCESS FOR PREPARING BRIDGESTONE AMERICAS TIRE OPERATIONS, LLC 2024-04-04 US disclosed
US-11932759-B1 Polymer-filler composites with guayule rubber BRIDGESTONE CORPORATION (JP) 2024-03-19 US disclosed
US-20060106143-A1 Silica-reinforced rubber compounded with blocked mercaptosilanes and alkyl alkoxysilanes BRIDGESTONE CORPORATION 2006-05-18 US disclosed
EP-1609516-A1 Process and device for extracting substances from silan-modified fillers Degussa AG (DE) 2005-12-28 EP disclosed
EP-1256604-B1 Biopolymers, biooligomers, oxidic or silicate Filler modified by silanes, method for its production and use DEGUSSA (DE) 2005-08-31 EP disclosed
EP-1357156-A2 Silane modified oxidic or silicate filler, method for its manufacture and its use Degussa AG (DE) 2003-10-29 EP disclosed
EP-1256604-A2 Biopolymers, biooligomers, oxidic or silicate Filler modified by silanes, method for its production and use Degussa AG (DE) 2002-11-13 EP disclosed