SCHEMBL3377985

SCHEMBL3377985

Cc1cccc(C(C=O)c2ccc(Br)cc2OC2CNC2)c1

nearest known ligand 0.53

Predicted protein targets (top 4)

geneUniProtsupporting neighboursconfidence
SLC6A4 P31645 9/20 0.47
HTR6 P50406 3/20 0.47
HTR2C P28335 2/20 0.47
HTR2B P41595 2/20 0.47

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL3380976 0.87 SLC6A4 (0.49) SLC6A4HTR6HTR2CHTR2B
SCHEMBL3378693 0.81 SLC6A4 (0.44) SLC6A4HTR6HTR2CHTR2B
SCHEMBL2287650 0.71 SLC6A4 (0.74) SLC6A4HTR6HTR2CHTR2B
SCHEMBL2289191 0.70 SLC6A4 (0.69) SLC6A4
SCHEMBL9729373 0.68 ACHE (0.46)
SCHEMBL3377987 0.67 SLC6A4 (0.46) SLC6A4HTR6
SCHEMBL2580468 0.65 SLC6A4 (0.64) SLC6A4HTR6
SCHEMBL14862428 0.65 SLC6A4 (0.64) SLC6A4HTR6
SCHEMBL2285622 0.65 SLC6A4 (1.00) SLC6A4HTR6HTR2CHTR2B
SCHEMBL2283205 0.64 SLC6A4 (1.00) SLC6A4HTR6HTR2CHTR2B

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
WO-2010059393-A1 SEROTONIN RECEPTOR MODULATORS JANSSEN PHARMACEUTICA NV (BE) 2010-05-27 WO claimed