Known targets — ChEMBL curated mechanism
ABL1ADRA1AADRA1BADRA1DADRA2AADRA2BADRA2CADRB2AGTR1BCL2BCL2A1BCL2L1BCL2L10BCL2L2BCRBRAFCHRM1CHRNA10CHRNA9DRD1DRD2DRD3DRD4DRD5EGFRF2FLT1FLT4GCKGHSRGNRHRGRIN1GRIN2AGRIN2BGRIN2CGRIN2DGRIN3AGRIN3BHTR1AHTR1BHTR1DHTR2AHTR2CHTR3AIDH2KDRKITMAOBMCL1MTTPPP4HBPDGFRBPIK3CAPIK3CBPIK3CDPIK3CGPIK3R1PIK3R2PIK3R3PIK3R5PIKFYVEROCK1ROCK2SLC18A2SLC6A2SLC6A3SLC6A4TACR1TUBA1ATUBA1BTUBA1CTUBA3CTUBA3ETUBA4ATUBBTUBB1TUBB2ATUBB2BTUBB3TUBB4ATUBB4BTUBB6TUBB8gyrAgyrBparCparEpol
The experimentally established mechanism targets of Benzamidine. The predicted profile below is derived independently by chemical similarity — agreement is a validation signal, a miss is honest.
Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | F2 known ✓ | P00734 | 3/20 | 0.70 |
| ▸ | F10 | P00742 | 1/20 | 0.70 |
| ▸ | F12 | P00748 | 1/20 | 0.70 |
| ▸ | F7 | P08709 | 1/20 | 0.70 |
| ▸ | F3 | P13726 | 1/20 | 0.70 |
| ▸ | PKM | P14618 | 1/20 | 0.70 |
| ▸ | BLM | P54132 | 2/20 | 0.67 |
| ▸ | PRSS1 | P07477 | 5/20 | 0.64 |
| ▸ | PRSS2 | P07478 | 5/20 | 0.64 |
| ▸ | PRSS3 | P35030 | 5/20 | 0.64 |
| ▸ | RECQL | P46063 | 2/20 | 0.64 |
| ▸ | C1S | P09871 | 1/20 | 0.64 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.64 |
| ▸ | TMPRSS6 | Q8IU80 | 3/20 | 0.56 |
| ▸ | WDR5 | P61964 | 1/20 | 0.54 |
| ▸ | NQO2 | P16083 | 6/20 | 0.46 |
| ▸ | POLB | P06746 | 1/20 | 0.44 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.44 |
| ▸ | PARP1 | P09874 | 1/20 | 0.44 |
| ▸ | MAPT | P10636 | 1/20 | 0.44 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| Benzamidine SCHEMBL2810507 | 1.00 | F2 (0.70) | F2F10F12F7F3 | |
| Benzamidine SCHEMBL27437547 | 0.98 | PRSS1 (0.68) | F2F10F12F7F3 | |
| Benzamidine SCHEMBL10711784 | 0.91 | F2 (0.76) | F2F10F12F7F3 | |
| Benzamidine SCHEMBL9123469 | 0.89 | F2 (0.73) | F2F10F12F7F3 | |
| Benzamidine SCHEMBL11393583 | 0.87 | F2 (0.70) | F2F10F12F7F3 | |
| Benzamidine SCHEMBL11628440 | 0.86 | F2 (0.61) | F2F10F12F7F3 | |
| Benzamidine SCHEMBL27322882 | 0.84 | F2 (0.89) | F2F10F12F7F3 | |
| Benzamidine SCHEMBL23067876 | 0.83 | F2 (1.00) | F2F10F12F7F3 | |
| Benzamidine SCHEMBL9207 | 0.83 | — | — | |
| SCHEMBL18557033 | 0.83 | F2 (1.00) | F2F10F12F7F3 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1701722-B1 | N-HYDROXY-4-{5-[4-(5-ISOPROPYL-2-METHYL-1,3-THIAZOL-4-YL)PHENOXY¨]PENTOXY}BENZAMIDINE 2 METHANSULFONIC ACID SALT | DONG WHA PHARM CO LTD (KR) | 2009-10-14 | — | — | EP | claimed |
| CN-102149380-B | A pharmaceutical composition for preventing or treating osteoporosis comprising benzamidine derivatives or their salts, and alendronic acid or its salt | DONG WHA PHARM CO LTD | 2012-12-05 | — | — | CN | disclosed |
| CN-102149380-A | A pharmaceutical composition for preventing or treating osteoporosis comprising benzamidine derivatives or their salts, and alendronic acid or its salt | DONG WHA PHARM CO LTD | 2011-08-10 | — | — | CN | disclosed |
| WO-2010013969-A2 | A PHARMACEUTICAL COMPOSITION FOR PREVENTING OR TREATING OSTEOPOROSIS COMPRISING BENZAMIDINE DERIVATIVES OR THEIR SALTS, AND ALENDRONIC ACID OR ITS SALT | DONG WHA PHARMACEUTICAL CO., LTD. (KR) | 2010-02-04 | — | — | WO | disclosed |