Predicted protein targets (top 16)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | P2RX7 | Q99572 | 4/20 | 0.37 |
| ▸ | CYP2D6 | P10635 | 2/20 | 0.37 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.37 |
| ▸ | FTO | Q9C0B1 | 2/20 | 0.36 |
| ▸ | ALPL | P05186 | 2/20 | 0.36 |
| ▸ | ALPI | P09923 | 2/20 | 0.36 |
| ▸ | ALPG | P10696 | 2/20 | 0.36 |
| ▸ | TP53 | P04637 | 1/20 | 0.36 |
| ▸ | CYP3A4 | P08684 | 2/20 | 0.36 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.34 |
| ▸ | MEN1 | O00255 | 1/20 | 0.34 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.34 |
| ▸ | CXCR4 | P61073 | 1/20 | 0.34 |
| ▸ | POLB | P06746 | 2/20 | 0.33 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.33 |
| ▸ | USP2 | O75604 | 1/20 | 0.33 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL3378689 | 0.85 | HRH3 (0.39) | P2RX7CYP2D6ALDH1A1FTOCYP3A4 | |
| SCHEMBL3378894 | 0.84 | P2RX7 (0.43) | P2RX7ALDH1A1ALPLALPIALPG | |
| SCHEMBL3380633 | 0.80 | P2RX7 (0.41) | P2RX7ALDH1A1ALPLALPIALPG | |
| SCHEMBL3378982 | 0.79 | P2RX7 (0.40) | P2RX7ALDH1A1ALPLALPIALPG | |
| SCHEMBL4646894 | 0.78 | P2RX7 (0.41) | P2RX7ALDH1A1ALPLALPIALPG | |
| Hydrochloric Acid SCHEMBL3380517 | 0.77 | CYP2D6 (0.42) | CYP2D6ALDH1A1FTOCYP3A4CYP2C9 | |
| Hydrochloric Acid SCHEMBL3380519 | 0.77 | CYP2D6 (0.42) | CYP2D6ALDH1A1FTOCYP3A4CYP2C9 | |
| Hydrochloric Acid SCHEMBL3379330 | 0.77 | P2RX7 (0.44) | P2RX7CYP2D6ALDH1A1ALPLALPI | |
| Hydrochloric Acid SCHEMBL3379328 | 0.77 | P2RX7 (0.44) | P2RX7CYP2D6ALDH1A1ALPLALPI | |
| SCHEMBL3375231 | 0.76 | P2RX7 (0.41) | P2RX7CYP2D6ALDH1A1CYP3A4 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1899296-B1 | HISTAMINE-3 RECEPTOR ANTAGONISTS | PFIZER PROD INC (US) | 2010-11-17 | — | — | EP | claimed |