Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | P2RX7 | Q99572 | 1/20 | 0.40 |
| ▸ | CYP2A13 | Q16696 | 1/20 | 0.38 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.37 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.37 |
| ▸ | POLB | P06746 | 1/20 | 0.37 |
| ▸ | CXCR4 | P61073 | 1/20 | 0.36 |
| ▸ | GSK3B | P49841 | 1/20 | 0.36 |
| ▸ | KCNH2 | Q12809 | 1/20 | 0.36 |
| ▸ | ACACB | O00763 | 1/20 | 0.36 |
| ▸ | ACACA | Q13085 | 1/20 | 0.36 |
| ▸ | TP53 | P04637 | 2/20 | 0.35 |
| ▸ | ALPL | P05186 | 1/20 | 0.35 |
| ▸ | ALPI | P09923 | 1/20 | 0.35 |
| ▸ | ALPG | P10696 | 1/20 | 0.35 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.35 |
| ▸ | BCHE | P06276 | 1/20 | 0.35 |
| ▸ | TSHR | P16473 | 1/20 | 0.35 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.35 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.35 |
| ▸ | MEN1 | O00255 | 2/20 | 0.35 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL3378894 | 0.87 | P2RX7 (0.43) | P2RX7KDM4EALDH1A1POLBCXCR4 | |
| SCHEMBL3380633 | 0.82 | P2RX7 (0.41) | P2RX7KDM4EALDH1A1POLBCXCR4 | |
| SCHEMBL3377159 | 0.82 | HRH3 (0.41) | P2RX7CYP2A13KDM4EALDH1A1POLB | |
| SCHEMBL4646894 | 0.80 | P2RX7 (0.41) | P2RX7KDM4EALDH1A1POLBTP53 | |
| SCHEMBL4647815 | 0.80 | P2RX7 (0.43) | P2RX7KDM4EALDH1A1POLBCXCR4 | |
| SCHEMBL3378700 | 0.79 | P2RX7 (0.37) | P2RX7KDM4EALDH1A1POLBCXCR4 | |
| SCHEMBL4648735 | 0.79 | P2RX7 (0.39) | P2RX7KDM4EALDH1A1POLBCXCR4 | |
| Hydrochloric Acid SCHEMBL3379328 | 0.79 | P2RX7 (0.44) | P2RX7KDM4EALDH1A1POLBCXCR4 | |
| Hydrochloric Acid SCHEMBL3379330 | 0.79 | P2RX7 (0.44) | P2RX7KDM4EALDH1A1POLBCXCR4 | |
| SCHEMBL3376438 | 0.78 | CYP2A13 (0.51) | P2RX7CYP2A13KDM4EALDH1A1POLB |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1899296-B1 | HISTAMINE-3 RECEPTOR ANTAGONISTS | PFIZER PROD INC (US) | 2010-11-17 | — | — | EP | claimed |