Predicted protein targets (top 9)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.41 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.40 |
| ▸ | MAPT | P10636 | 1/20 | 0.40 |
| ▸ | PTGS2 | P35354 | 2/20 | 0.36 |
| ▸ | SCN9A | Q15858 | 1/20 | 0.35 |
| ▸ | NR1D1 | P20393 | 1/20 | 0.34 |
| ▸ | RAB9A | P51151 | 1/20 | 0.34 |
| ▸ | POLB | P06746 | 1/20 | 0.33 |
| ▸ | LMNA | P02545 | 1/20 | 0.33 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL3379013 | 0.72 | ALDH1A1 (0.56) | ALDH1A1KDM4EMAPTPTGS2RAB9A | |
| SCHEMBL31518476 | 0.67 | ALDH1A1 (0.47) | ALDH1A1KDM4EPOLBLMNA | |
| SCHEMBL24279552 | 0.65 | MAPT (0.50) | ALDH1A1KDM4EMAPTRAB9APOLB | |
| SCHEMBL6507783 | 0.65 | KMT2A (0.52) | ALDH1A1KDM4EMAPTNR1D1RAB9A | |
| SCHEMBL8302189 | 0.65 | SMN1; SMN2 (0.46) | ALDH1A1MAPTRAB9ALMNA | |
| SCHEMBL3376989 | 0.65 | SMN1; SMN2 (0.54) | ALDH1A1KDM4EMAPTRAB9ALMNA | |
| SCHEMBL14805378 | 0.63 | SMN1; SMN2 (0.43) | ALDH1A1KDM4EMAPTRAB9APOLB | |
| SCHEMBL3375789 | 0.63 | POLB (0.38) | ALDH1A1MAPTPTGS2SCN9ARAB9A | |
| SCHEMBL31518395 | 0.61 | ALDH1A1 (0.45) | ALDH1A1RAB9APOLBLMNA | |
| SCHEMBL22304643 | 0.61 | GRM2 (0.40) | — |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2010056527-A2 | FUSED HETEROCYCLIC COMPOUNDS AS ION CHANNEL MODULATORS | GILEAD PALO ALTO, INC. (US) | 2010-05-20 | — | — | WO | disclosed |