Predicted protein targets (top 17)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | SMN1; SMN2 | Q16637 | 4/20 | 0.46 |
| ▸ | LMNA | P02545 | 2/20 | 0.46 |
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.44 |
| ▸ | MMP2 | P08253 | 3/20 | 0.44 |
| ▸ | MMP9 | P14780 | 3/20 | 0.44 |
| ▸ | RAB9A | P51151 | 1/20 | 0.44 |
| ▸ | GAA | P10253 | 1/20 | 0.42 |
| ▸ | PTPN1 | P18031 | 2/20 | 0.42 |
| ▸ | PTPN6 | P29350 | 1/20 | 0.42 |
| ▸ | PTPN11 | Q06124 | 1/20 | 0.42 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.42 |
| ▸ | PER2 | O15055 | 1/20 | 0.41 |
| ▸ | CRY1 | Q16526 | 1/20 | 0.41 |
| ▸ | CRY2 | Q49AN0 | 1/20 | 0.41 |
| ▸ | MEN1 | O00255 | 1/20 | 0.38 |
| ▸ | MAPT | P10636 | 1/20 | 0.38 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.38 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL14805378 | 0.83 | SMN1; SMN2 (0.43) | SMN1; SMN2LMNAALDH1A1MMP2MMP9 | |
| SCHEMBL24279552 | 0.83 | MAPT (0.50) | SMN1; SMN2LMNAALDH1A1MMP2MMP9 | |
| SCHEMBL1409649 | 0.79 | SMN1; SMN2 (0.63) | SMN1; SMN2LMNAALDH1A1MMP2MMP9 | |
| SCHEMBL4935409 | 0.77 | ALDH1A1 (0.48) | SMN1; SMN2LMNAALDH1A1MMP2MMP9 | |
| SCHEMBL2378054 | 0.76 | SMN1; SMN2 (0.39) | SMN1; SMN2LMNAALDH1A1MMP2MMP9 | |
| SCHEMBL31518476 | 0.71 | ALDH1A1 (0.47) | SMN1; SMN2LMNAALDH1A1MAPK1MEN1 | |
| SCHEMBL18346856 | 0.71 | PER2 (0.47) | SMN1; SMN2LMNAALDH1A1MMP2MMP9 | |
| SCHEMBL10000463 | 0.70 | NCEH1 (0.44) | SMN1; SMN2LMNAALDH1A1MAPK1MAPT | |
| SCHEMBL2194247 | 0.70 | SMN1; SMN2 (0.49) | SMN1; SMN2LMNAALDH1A1MMP2MMP9 | |
| SCHEMBL3379013 | 0.70 | ALDH1A1 (0.56) | SMN1; SMN2LMNAALDH1A1RAB9AMAPK1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 5 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20080227858-A1 | Inhibitors of matrix metalloproteinase | GLAXO GROUP LIMITED | 2008-09-18 | — | — | US | disclosed |
| US-20080227858-A1 | Inhibitors of matrix metalloproteinase | GLAXO GROUP LIMITED | 2008-09-18 | — | — | US | disclosed |
| US-7375248-B2 | Inhibitors of matrix metalloproteinase | GLAXO GROUP LIMITED (GB) | 2008-05-20 | — | — | US | disclosed |
| US-7375248-B2 | Inhibitors of matrix metalloproteinase | GLAXO GROUP LIMITED (GB) | 2008-05-20 | — | — | US | disclosed |
| WO-2004113279-A1 | INHIBITORS OF MATRIX METALLOPROTEINASE | GLAXO GROUP LIMITED (GB) | 2004-12-29 | — | — | WO | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20080227858-A1 | Inhibitors of matrix metalloproteinase | MMP9, MMP13, MMP2 | SMN1; SMN2 3365/4885LMNA 3942/4885ALDH1A1 3221/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.