SCHEMBL3380244

SCHEMBL3380244

COc1ccccc1-c1ccccc1S(N)(=O)=O

nearest known ligand 0.49

Predicted protein targets (top 20)

geneUniProtsupporting neighboursconfidence
HTR6 P50406 1/20 0.49
SCN9A Q15858 1/20 0.48
PTGES2 Q9H7Z7 2/20 0.47
CA2 P00918 8/20 0.46
CA1 P00915 7/20 0.46
CA9 Q16790 6/20 0.46
CA12 O43570 4/20 0.46
CA5A P35218 2/20 0.46
PKM P14618 1/20 0.44
APP P05067 1/20 0.44
KDM4E B2RXH2 1/20 0.44
MEN1 O00255 1/20 0.44
USP2 O75604 1/20 0.44
ALDH1A1 P00352 1/20 0.44
MAPT P10636 1/20 0.44
DUSP3 P51452 1/20 0.44
KMT2A Q03164 1/20 0.44
TDP1 Q9NUW8 1/20 0.44
CA4 P22748 2/20 0.44
CA6 P23280 2/20 0.44

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL28890398 0.98 HTR6 (0.47) HTR6SCN9APTGES2CA2CA1
SCHEMBL28404238 0.87 PTPRC (0.44) HTR6SCN9APTGES2CA2CA1
SCHEMBL3819215 0.86 CA2 (0.44) HTR6SCN9APTGES2CA2CA1
SCHEMBL29581383 0.84 HTR6 (0.60) HTR6PTGES2CA2CA1CA9
SCHEMBL529620 0.84 HTR6 (0.60) HTR6PTGES2CA2CA1CA9
SCHEMBL29700095 0.83 HTR6 (0.50) HTR6CA2CA1CA9CA12
Hydrochloric Acid SCHEMBL29713481 0.82 HTR6 (0.58) HTR6PTGES2CA2CA1CA9
Hydrochloric Acid SCHEMBL4910433 0.82 HTR6 (0.58) HTR6PTGES2CA2CA1CA9
SCHEMBL3819210 0.82 STAT3 (0.47) HTR6SCN9APTGES2CA2CA1
SCHEMBL1080972 0.82 CA2 (0.61) CA2CA1CA9CA12CA5A

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
WO-2010005534-A2 PROTEASOME INHIBITORS FOR SELECTIVELY INDUCING APOPTOSIS IN CANCER CELLS H. LEE MOFFITT CANCER CENTER AND RESEARCH INSTITUTE, INC. (US) 2010-01-14 WO disclosed
EP-2007760-A1 NOVEL SUBSTITUTED-1, 1-DIOXO-BENZO[1,2,4]THIADIZIN-3-ONES, PREPARATION METHOD THEREOF, AND PHARMACEUTICAL COMPOSITION CONTAINING THE SAME KOREA RESEARCH INSTITUTE OF CHEMICAL TECHNOLOGY (KR) 2008-12-31 EP disclosed
WO-2007108569-A1 NOVEL SUBSTITUTED-1, 1-DIOXO-BENZO[1,2,4]THIADIZIN-3-ONES, PREPARATION METHOD THEREOF, AND PHARMACEUTICAL COMPOSITION CONTAINING THE SAME KOREA RESERACH INSTITUTE OF CHEMICAL TECHNOLOGY (KR) 2007-09-27 WO disclosed