Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | GPR139 | Q6DWJ6 | 6/20 | 0.47 |
| ▸ | MMP9 | P14780 | 1/20 | 0.46 |
| ▸ | MMP8 | P22894 | 1/20 | 0.46 |
| ▸ | MMP14 | P50281 | 1/20 | 0.46 |
| ▸ | MAPT | P10636 | 3/20 | 0.46 |
| ▸ | HPGD | P15428 | 2/20 | 0.46 |
| ▸ | LMNA | P02545 | 1/20 | 0.46 |
| ▸ | CRHBP | P24387 | 1/20 | 0.46 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.46 |
| ▸ | CRHR2 | Q13324 | 1/20 | 0.46 |
| ▸ | GAA | P10253 | 1/20 | 0.44 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.44 |
| ▸ | KMT2A | Q03164 | 4/20 | 0.44 |
| ▸ | MEN1 | O00255 | 3/20 | 0.43 |
| ▸ | POLB | P06746 | 1/20 | 0.43 |
| ▸ | NPC1 | O15118 | 1/20 | 0.43 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.43 |
| ▸ | CYP2D6 | P10635 | 1/20 | 0.43 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.43 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.43 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL338031 | 1.00 | GPR139 (0.47) | GPR139MMP9MMP8MMP14MAPT | |
| SCHEMBL338943 | 1.00 | GPR139 (0.47) | GPR139MMP9MMP8MMP14MAPT | |
| SCHEMBL11931667 | 1.00 | GPR139 (0.47) | GPR139MMP9MMP8MMP14MAPT | |
| SCHEMBL14448601 | 0.83 | GPR139 (0.45) | GPR139MMP9MMP8MMP14MAPT | |
| SCHEMBL3865686 | 0.81 | MAPT (0.52) | GPR139MMP9MMP8MMP14MAPT | |
| SCHEMBL8244522 | 0.81 | MAPT (0.52) | GPR139MMP9MMP8MMP14MAPT | |
| SCHEMBL13759541 | 0.81 | MAPT (0.52) | GPR139MMP9MMP8MMP14MAPT | |
| SCHEMBL337773 | 0.81 | MAPT (0.52) | GPR139MMP9MMP8MMP14MAPT | |
| SCHEMBL3773115 | 0.81 | MAPT (0.52) | GPR139MMP9MMP8MMP14MAPT | |
| SCHEMBL8248506 | 0.81 | MAPT (0.52) | GPR139MMP9MMP8MMP14MAPT |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 21 patents — showing the first 20. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1841726-B1 | AN ASYMMETRIC SYNTHESIS OF (S)-(+)-3-(AMINOMETHYL)-5-METHYLHEXANOIC ACID | TEVA PHARMA (IL) | 2012-10-31 | — | — | EP | disclosed |
| US-8212071-B2 | Asymmetric synthesis of (S)-(+)-3-(aminomethyl)-5-methylhexanoic acid | TEVA PHARMACEUTICAL INDUSTRIES LTD. (IL) | 2012-07-03 | — | — | US | disclosed |
| US-8097754-B2 | Synthesis of (S)-(+)-3-(aminomethyl)-5-methyl hexanoic acid | TEVA PHARMACEUTICAL INDUSTRIES LTD. (IL) | 2012-01-17 | — | — | US | disclosed |
| US-7973196-B2 | Asymmetric synthesis of (S)-(+)-3-(aminomethyl)-5-methylhexanoic acid | TEVA PHARMACEUTICAL INDUSTRIES LTD. (IL) | 2011-07-05 | — | — | US | disclosed |
| US-7960583-B2 | Asymmetric synthesis of (S)-(+)-3-(aminomethyl)-5-methylhexanoic acid | TEVA PHARMACEUTICAL INDUSTRIES LTD. (IL) | 2011-06-14 | — | — | US | disclosed |
| US-7923575-B2 | Asymmetric synthesis of (S)-(+)-3-(aminomethyl)-5-methylhexanoic acid | TEVA PHARMACEUTICAL INDUSTRIES LIMITED (IL) | 2011-04-12 | — | — | US | disclosed |
| US-20100324307-A1 | NOVEL ASYMMETRIC SYNTHESIS OF (S)-(+)-3-(AMINOMETHYL)-5-METHYLHEXANOIC ACID | KANSAL VINOD KUMAR | 2010-12-23 | — | — | US | disclosed |
| US-7851651-B2 | Asymmetric synthesis of (S)-(+)-3-(aminomethyl)-5-methylhexanoic acid | TEVA PHARMACEUTICAL INDUSTRIES LTD. (IL) | 2010-12-14 | — | — | US | disclosed |
| US-20100081841-A1 | Novel asymmetric synthesis of (s)-(+)-3-(AMINOMETHYL)-5- methylhexanoic acid | KANSAL VINOD KUMAR | 2010-04-01 | — | — | US | disclosed |
| US-7687656-B2 | Asymmetric synthesis of (S)-(+)-3-(aminomethyl)-5-methylhexanoic acid | TEVA PHARMACEUTICAL INDUSTRIES LTD. (IL) | 2010-03-30 | — | — | US | disclosed |
| US-20090069596-A1 | Novel asymmetric synthesis of (S)-(+)-3-(aminomethyl)-5-methylhexanoic acid | KANSAL VINOD KUMAR | 2009-03-12 | — | — | US | disclosed |
| US-20090069578-A1 | Novel asymmetric synthesis of (S)-(+)-3-(aminomethyl)-5-methylhexanoic acid | KANSAL VINOD KUMAR | 2009-03-12 | — | — | US | disclosed |
| US-20090069600-A1 | Novel asymmetric synthesis of (S)-(+)-3-(aminomethyl)-5-methylhexanoic acid | KANSAL VINOD KUMAR | 2009-03-12 | — | — | US | disclosed |
| US-20090062562-A1 | Novel asymmetric synthesis of (S)-(+)-3-(Aminomethyl)-5-methylhexanoic acid | KANSAL VINOD KUMAR | 2009-03-05 | — | — | US | disclosed |
| EP-2021318-A2 | SYNTHESIS OF (S)-(+)-3-(AMINOMETHYL)-5-METHYL HEXANOIC ACID | Teva Pharmaceutical Industries Ltd. (IL) | 2009-02-11 | — | — | EP | disclosed |
| WO-2008118427-A9 | SYNTHESIS OF (S)-(+)-3-(AMINOMETHYL)-5-METHYL HEXANOIC ACID | TEVA PHARMA (IL) | 2009-02-05 | — | — | WO | disclosed |
| US-20080306292-A1 | Synthesis of (S)-(+)-3-(aminomethyl)-5-methyl hexanoic acid | TEVA PHARMACEUTICAL INDUSTRIES LTD. (IL) | 2008-12-11 | — | — | US | disclosed |
| US-7446220-B2 | Asymmetric synthesis of (S)-(+)-3-(aminomethyl)-5-methylhexanoic acid | TEVA PHARMACEUTICAL INDUSTRIES LTD. (IL) | 2008-11-04 | — | — | US | disclosed |
| WO-2008118427-A2 | SYNTHESIS OF (S)-(+)-3-(AMINOMETHYL)-5-METHYL HEXANOIC ACID | TEVA PHARMACEUTICAL INDUSTRIES LTD. (IL) | 2008-10-02 | — | — | WO | disclosed |
| US-20070197827-A1 | Novel asymmetric synthesis of (S)-(+)-3-(aminomethyl)-5-methylhexanoic acid | TEVA PHARMACEUTICAL INDUSTRIES LTD. (IL) | 2007-08-23 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (8 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20070197827-A1 | Novel asymmetric synthesis of (S)-(+)-3-(aminomethyl)-5-methylhexanoic acid | RIMKLA, COASY, GABRE | GPR139 1403/4885MMP9 4638/4885MMP8 4884/4885 |
| US-20090069596-A1 | Novel asymmetric synthesis of (S)-(+)-3-(aminomethyl)-5-methylhexanoic acid | RIMKLA, COASY, GABRE | GPR139 1403/4885MMP9 4638/4885MMP8 4884/4885 |
| US-20100081841-A1 | Novel asymmetric synthesis of (s)-(+)-3-(AMINOMETHYL)-5- methylhexanoic acid | RIMKLA, COASY, GABRE | GPR139 1403/4885MMP9 4638/4885MMP8 4884/4885 |
| US-20080306292-A1 | Synthesis of (S)-(+)-3-(aminomethyl)-5-methyl hexanoic acid | ADSL, RIMKLA, ACSL6 | GPR139 483/4885MMP9 4422/4885MMP8 4882/4885 |
| US-20100324307-A1 | NOVEL ASYMMETRIC SYNTHESIS OF (S)-(+)-3-(AMINOMETHYL)-5-METHYLHEXANOIC ACID | RIMKLA, COASY, GABRE | GPR139 1403/4885MMP9 4638/4885MMP8 4884/4885 |
| US-20090062562-A1 | Novel asymmetric synthesis of (S)-(+)-3-(Aminomethyl)-5-methylhexanoic acid | RIMKLA, COASY, GABRE | GPR139 1403/4885MMP9 4638/4885MMP8 4884/4885 |
| US-20090069578-A1 | Novel asymmetric synthesis of (S)-(+)-3-(aminomethyl)-5-methylhexanoic acid | RIMKLA, COASY, GABRE | GPR139 1403/4885MMP9 4638/4885MMP8 4884/4885 |
| US-20090069600-A1 | Novel asymmetric synthesis of (S)-(+)-3-(aminomethyl)-5-methylhexanoic acid | RIMKLA, COASY, GABRE | GPR139 1403/4885MMP9 4638/4885MMP8 4884/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.