Predicted protein targets (top 13)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | POLB | P06746 | 1/20 | 0.57 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.57 |
| ▸ | HTR2A | P28223 | 4/20 | 0.51 |
| ▸ | HTR2C | P28335 | 13/20 | 0.42 |
| ▸ | CHRM4 | P08173 | 1/20 | 0.42 |
| ▸ | CHRM5 | P08912 | 1/20 | 0.42 |
| ▸ | CHRM1 | P11229 | 1/20 | 0.42 |
| ▸ | CHRM3 | P20309 | 1/20 | 0.42 |
| ▸ | HTR3A | P46098 | 1/20 | 0.42 |
| ▸ | HTR6 | P50406 | 1/20 | 0.42 |
| ▸ | HTR2B | P41595 | 9/20 | 0.40 |
| ▸ | LMNA | P02545 | 1/20 | 0.37 |
| ▸ | MAPT | P10636 | 1/20 | 0.37 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL22720338 | 0.79 | SMN1; SMN2 (0.76) | POLBSMN1; SMN2HTR2AHTR2CCHRM4 | |
| SCHEMBL25677916 | 0.77 | HTR2C (0.56) | POLBSMN1; SMN2HTR2AHTR2CLMNA | |
| SCHEMBL8898686 | 0.77 | SMN1; SMN2 (0.54) | POLBSMN1; SMN2HTR2AHTR2CLMNA | |
| SCHEMBL4071219 | 0.77 | POLB (0.54) | POLBSMN1; SMN2HTR2AHTR2CCHRM4 | |
| Hydrochloric Acid SCHEMBL8898072 | 0.76 | SMN1; SMN2 (0.52) | POLBSMN1; SMN2HTR2AHTR2CLMNA | |
| SCHEMBL4011767 | 0.75 | HTR2A (0.61) | HTR2AHTR2CCHRM4CHRM5CHRM1 | |
| Hydrochloric Acid SCHEMBL4203716 | 0.73 | HTR2C (0.60) | HTR2AHTR2CHTR3AHTR6HTR2B | |
| SCHEMBL1020021 | 0.73 | POLB (0.72) | POLBSMN1; SMN2HTR2C | |
| SCHEMBL1622748 | 0.72 | HTR2A (0.82) | SMN1; SMN2HTR2AHTR2CHTR2B | |
| SCHEMBL24920554 | 0.70 | LMNA (0.50) | POLBSMN1; SMN2LMNAMAPT |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2010053825-A1 | 2-AMINOPYRIMIDINE COMPOUNDS AS SEROTONIN RECEPTOR MODULATORS | JANSSEN PHARMACEUTICA NV (BE) | 2010-05-14 | — | — | WO | claimed |