Predicted protein targets (top 16)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | LMNA | P02545 | 6/20 | 0.50 |
| ▸ | MAPT | P10636 | 6/20 | 0.50 |
| ▸ | POLB | P06746 | 2/20 | 0.50 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.49 |
| ▸ | TP53 | P04637 | 3/20 | 0.48 |
| ▸ | HSP90AB1 | P08238 | 3/20 | 0.46 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.43 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.43 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.43 |
| ▸ | HPGD | P15428 | 1/20 | 0.43 |
| ▸ | TSHR | P16473 | 1/20 | 0.43 |
| ▸ | CASP1 | P29466 | 1/20 | 0.43 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.43 |
| ▸ | CASP7 | P55210 | 1/20 | 0.43 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.43 |
| ▸ | HSP90AA1 | P07900 | 1/20 | 0.43 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL24920545 | 0.89 | POLB (0.46) | LMNAMAPTPOLBSMN1; SMN2TP53 | |
| SCHEMBL24920528 | 0.88 | LMNA (0.61) | LMNAMAPTPOLBTP53HSP90AB1 | |
| SCHEMBL24920531 | 0.83 | HSP90AB1 (0.56) | LMNAMAPTPOLBTP53HSP90AB1 | |
| SCHEMBL26066293 | 0.82 | POLB (0.46) | LMNAMAPTPOLBSMN1; SMN2TP53 | |
| SCHEMBL24922040 | 0.81 | LMNA (0.44) | LMNAMAPTPOLBSMN1; SMN2TP53 | |
| SCHEMBL24920540 | 0.80 | LMNA (0.47) | LMNAMAPTPOLBTP53HSP90AB1 | |
| SCHEMBL25677916 | 0.79 | HTR2C (0.56) | LMNAMAPTPOLBSMN1; SMN2HSP90AB1 | |
| SCHEMBL8898686 | 0.79 | SMN1; SMN2 (0.54) | LMNAMAPTPOLBSMN1; SMN2TP53 | |
| SCHEMBL30405241 | 0.79 | MAPT (0.52) | LMNAMAPTPOLBSMN1; SMN2TP53 | |
| SCHEMBL28516998 | 0.79 | MAPT (0.52) | LMNAMAPTPOLBSMN1; SMN2TP53 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-4234031-A2 | C40-, C28-, AND C-32-LINKED RAPAMYCIN ANALOGS AS MTOR INHIBITORS | Revolution Medicines, Inc. (US) | 2023-08-30 | — | — | EP | disclosed |
| WO-2023006097-A1 | BIFUNCTIONAL CHIMERIC HETEROCYCLIC COMPOUND AND USE THEREOF AS ANDROGEN RECEPTOR DEGRADER | 海创药业股份有限公司 | 2023-02-02 | — | — | WO | disclosed |