Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HRH3 | Q9Y5N1 | 1/20 | 0.49 |
| ▸ | FFAR1 | O14842 | 1/20 | 0.36 |
| ▸ | CHEK1 | O14757 | 1/20 | 0.36 |
| ▸ | RPS6KB1 | P23443 | 1/20 | 0.36 |
| ▸ | FLT4 | P35916 | 1/20 | 0.36 |
| ▸ | FLT3 | P36888 | 1/20 | 0.36 |
| ▸ | RPS6KA3 | P51812 | 1/20 | 0.36 |
| ▸ | PRKAA1 | Q13131 | 1/20 | 0.36 |
| ▸ | PRKD2 | Q9BZL6 | 1/20 | 0.36 |
| ▸ | GSK3B | P49841 | 1/20 | 0.36 |
| ▸ | ADRB2 | P07550 | 1/20 | 0.35 |
| ▸ | MLNR | O43193 | 2/20 | 0.35 |
| ▸ | GHSR | Q92847 | 1/20 | 0.35 |
| ▸ | KCNH2 | Q12809 | 2/20 | 0.35 |
| ▸ | OPRM1 | P35372 | 1/20 | 0.35 |
| ▸ | OPRD1 | P41143 | 1/20 | 0.35 |
| ▸ | OPRK1 | P41145 | 1/20 | 0.35 |
| ▸ | HRH1 | P35367 | 1/20 | 0.35 |
| ▸ | CCR3 | P51677 | 1/20 | 0.35 |
| ▸ | LSS | P48449 | 1/20 | 0.34 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL3380414 | 0.85 | HRH3 (0.47) | HRH3FLT4GSK3BMLNRKCNH2 | |
| SCHEMBL3381646 | 0.85 | HRH3 (0.49) | HRH3CHEK1RPS6KB1FLT4FLT3 | |
| SCHEMBL3414223 | 0.85 | HRH3 (0.48) | HRH3MLNRKCNH2HRH1CCR3 | |
| SCHEMBL3375225 | 0.84 | HRH3 (0.47) | HRH3GSK3BADRB2MLNRKCNH2 | |
| SCHEMBL3375675 | 0.84 | HRH3 (0.49) | HRH3FFAR1KCNH2OPRM1OPRD1 | |
| SCHEMBL3377866 | 0.83 | HRH3 (0.48) | HRH3GSK3BADRB2MLNRKCNH2 | |
| SCHEMBL3375063 | 0.82 | HRH3 (0.70) | HRH3ADRB2MLNRKCNH2OPRM1 | |
| SCHEMBL3377922 | 0.82 | HRH3 (0.54) | HRH3ADRB2MLNRKCNH2HRH1 | |
| Cyclopropane SCHEMBL3413689 | 0.81 | HRH3 (0.57) | HRH3MLNRKCNH2HRH1CCR3 | |
| SCHEMBL3381173 | 0.81 | HRH3 (0.57) | HRH3MLNRKCNH2HRH1CCR3 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1899296-B1 | HISTAMINE-3 RECEPTOR ANTAGONISTS | PFIZER PROD INC (US) | 2010-11-17 | — | — | EP | claimed |