Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | GAA | P10253 | 5/20 | 0.51 |
| ▸ | NPSR1 | Q6W5P4 | 2/20 | 0.51 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.51 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.51 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.51 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.51 |
| ▸ | ALDH1A1 | P00352 | 6/20 | 0.49 |
| ▸ | USP2 | O75604 | 2/20 | 0.49 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.49 |
| ▸ | RAB9A | P51151 | 1/20 | 0.49 |
| ▸ | CACNA1F | O60840 | 2/20 | 0.49 |
| ▸ | CACNA1D | Q01668 | 2/20 | 0.49 |
| ▸ | CACNA1S | Q13698 | 2/20 | 0.49 |
| ▸ | CACNA1C | Q13936 | 2/20 | 0.49 |
| ▸ | KDM4E | B2RXH2 | 6/20 | 0.48 |
| ▸ | TP53 | P04637 | 3/20 | 0.48 |
| ▸ | HSD17B10 | Q99714 | 3/20 | 0.48 |
| ▸ | GLA | P06280 | 2/20 | 0.48 |
| ▸ | HPGD | P15428 | 2/20 | 0.48 |
| ▸ | CASP1 | P29466 | 2/20 | 0.48 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL3320674 | 0.94 | GAA (0.60) | GAANPSR1CYP1A2CYP3A4CYP2C9 | |
| SCHEMBL5310139 | 0.91 | ALDH1A1 (0.57) | GAANPSR1CYP1A2CYP3A4CYP2C9 | |
| SCHEMBL3326126 | 0.87 | GAA (0.63) | GAANPSR1CYP1A2CYP3A4CYP2C9 | |
| SCHEMBL3330312 | 0.87 | GAA (0.61) | GAAALDH1A1USP2MAPK1RAB9A | |
| SCHEMBL3324008 | 0.86 | CACNA1F (0.61) | GAANPSR1ALDH1A1USP2MAPK1 | |
| SCHEMBL5314821 | 0.81 | CACNA1F (0.51) | GAANPSR1ALDH1A1USP2MAPK1 | |
| SCHEMBL5334201 | 0.81 | ALDH1A1 (0.54) | GAANPSR1CYP1A2CYP3A4CYP2C9 | |
| SCHEMBL5337018 | 0.81 | ALDH1A1 (0.53) | GAANPSR1ALDH1A1USP2MAPK1 | |
| SCHEMBL3325492 | 0.81 | KDM4E (0.56) | GAANPSR1CYP1A2CYP3A4CYP2C9 | |
| SCHEMBL3324462 | 0.80 | CACNA1F (0.50) | NPSR1ALDH1A1USP2MAPK1RAB9A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20100119599-A1 | POLYHYDROQUINOLINE COMPOUNDS AND DIHYDROPYRIDINE COMPOUNDS FOR INHIBITING BETA-AMYLOID PRODUCTION | ARCHER PHARMACEUTICALS, INC. (US) | 2010-05-13 | — | — | US | disclosed |
| US-20100119599-A1 | POLYHYDROQUINOLINE COMPOUNDS AND DIHYDROPYRIDINE COMPOUNDS FOR INHIBITING BETA-AMYLOID PRODUCTION | ARCHER PHARMACEUTICALS, INC. (US) | 2010-05-13 | — | — | US | disclosed |
| US-20100119599-A1 | POLYHYDROQUINOLINE COMPOUNDS AND DIHYDROPYRIDINE COMPOUNDS FOR INHIBITING BETA-AMYLOID PRODUCTION | ARCHER PHARMACEUTICALS, INC. (US) | 2010-05-13 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20100119599-A1 | POLYHYDROQUINOLINE COMPOUNDS AND DIHYDROPYRIDINE COMPOUNDS FOR INHIBITING BETA-AMYLOID PRODUCTION | APP, MAPT, PSEN1 | GAA 271/4885NPSR1 3203/4885CYP1A2 2214/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.