Predicted protein targets (top 14)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ALDH1A1 | P00352 | 5/20 | 0.39 |
| ▸ | CYP2D6 | P10635 | 2/20 | 0.39 |
| ▸ | CYP3A4 | P08684 | 2/20 | 0.38 |
| ▸ | KDM4E | B2RXH2 | 6/20 | 0.38 |
| ▸ | TSHR | P16473 | 1/20 | 0.38 |
| ▸ | TAS2R8 | Q9NYW2 | 2/20 | 0.37 |
| ▸ | MEN1 | O00255 | 5/20 | 0.37 |
| ▸ | KMT2A | Q03164 | 5/20 | 0.37 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.36 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.35 |
| ▸ | LMNA | P02545 | 1/20 | 0.35 |
| ▸ | MAPT | P10636 | 1/20 | 0.35 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.35 |
| ▸ | HRH3 | Q9Y5N1 | 1/20 | 0.35 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL3378689 | 0.91 | HRH3 (0.39) | ALDH1A1CYP2D6CYP3A4KDM4ETAS2R8 | |
| SCHEMBL3380116 | 0.91 | CYP2D6 (0.36) | ALDH1A1CYP2D6CYP3A4TAS2R8MEN1 | |
| SCHEMBL3375226 | 0.83 | HRH3 (0.42) | LMNAHRH3 | |
| SCHEMBL3377861 | 0.82 | KDM4E (0.43) | ALDH1A1KDM4ETSHRMEN1KMT2A | |
| SCHEMBL3378145 | 0.81 | KDM4E (0.45) | ALDH1A1KDM4ETSHRMEN1KMT2A | |
| SCHEMBL3377365 | 0.81 | HRH3 (0.47) | LMNAHRH3 | |
| SCHEMBL3381390 | 0.78 | HTR2C (0.33) | ALDH1A1KDM4EMEN1KMT2ALMNA | |
| SCHEMBL3377874 | 0.77 | HRH3 (0.39) | ALDH1A1KDM4EMEN1KMT2ALMNA | |
| Hydrochloric Acid SCHEMBL3380517 | 0.77 | CYP2D6 (0.42) | ALDH1A1CYP2D6CYP3A4TSHRMEN1 | |
| Hydrochloric Acid SCHEMBL3380519 | 0.77 | CYP2D6 (0.42) | ALDH1A1CYP2D6CYP3A4TSHRMEN1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1899296-B1 | HISTAMINE-3 RECEPTOR ANTAGONISTS | PFIZER PROD INC (US) | 2010-11-17 | — | — | EP | claimed |