Predicted protein targets (top 12)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CYP2D6 | P10635 | 2/20 | 0.36 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.36 |
| ▸ | CYP3A4 | P08684 | 2/20 | 0.35 |
| ▸ | HRH3 | Q9Y5N1 | 2/20 | 0.35 |
| ▸ | GRIN1 | Q05586 | 3/20 | 0.34 |
| ▸ | GRIN2B | Q13224 | 3/20 | 0.34 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.33 |
| ▸ | KMT2A | Q03164 | 4/20 | 0.33 |
| ▸ | MEN1 | O00255 | 3/20 | 0.33 |
| ▸ | P2RX7 | Q99572 | 2/20 | 0.32 |
| ▸ | SIRT2 | Q8IXJ6 | 3/20 | 0.32 |
| ▸ | TAS2R8 | Q9NYW2 | 1/20 | 0.31 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL3378689 | 0.91 | HRH3 (0.39) | CYP2D6ALDH1A1CYP3A4HRH3CYP2C9 | |
| SCHEMBL3380644 | 0.91 | ALDH1A1 (0.39) | CYP2D6ALDH1A1CYP3A4HRH3CYP2C9 | |
| Hydrochloric Acid SCHEMBL3380991 | 0.86 | CYP2D6 (0.41) | CYP2D6ALDH1A1CYP3A4HRH3GRIN1 | |
| Hydrochloric Acid SCHEMBL3380987 | 0.86 | CYP2D6 (0.41) | CYP2D6ALDH1A1CYP3A4HRH3GRIN1 | |
| SCHEMBL3375226 | 0.83 | HRH3 (0.42) | HRH3 | |
| SCHEMBL3381390 | 0.81 | HTR2C (0.33) | ALDH1A1HRH3KMT2AMEN1 | |
| SCHEMBL3377784 | 0.81 | MEN1 (0.46) | ALDH1A1HRH3GRIN1GRIN2BKMT2A | |
| SCHEMBL3377782 | 0.81 | MEN1 (0.46) | ALDH1A1HRH3GRIN1GRIN2BKMT2A | |
| SCHEMBL3377365 | 0.81 | HRH3 (0.47) | HRH3P2RX7 | |
| SCHEMBL3377536 | 0.80 | KMT2A (0.38) | ALDH1A1HRH3GRIN1GRIN2BKMT2A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1899296-B1 | HISTAMINE-3 RECEPTOR ANTAGONISTS | PFIZER PROD INC (US) | 2010-11-17 | — | — | EP | claimed |