Predicted protein targets (top 18)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CYP1A2 | P05177 | 1/20 | 0.57 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.57 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.57 |
| ▸ | ADRA2A | P08913 | 1/20 | 0.43 |
| ▸ | CLCN2 | P51788 | 1/20 | 0.43 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.38 |
| ▸ | MAPT | P10636 | 2/20 | 0.38 |
| ▸ | MEN1 | O00255 | 1/20 | 0.38 |
| ▸ | GAA | P10253 | 1/20 | 0.38 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.38 |
| ▸ | SIRT1 | Q96EB6 | 6/20 | 0.36 |
| ▸ | POLB | P06746 | 1/20 | 0.35 |
| ▸ | CAPN1 | P07384 | 1/20 | 0.34 |
| ▸ | CTSL | P07711 | 1/20 | 0.34 |
| ▸ | CTSB | P07858 | 1/20 | 0.34 |
| ▸ | CTSH | P09668 | 1/20 | 0.34 |
| ▸ | P2RX7 | Q99572 | 1/20 | 0.33 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.33 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL4744827 | 0.88 | CYP1A2 (0.73) | CYP1A2CYP3A4CYP2C19KDM4EMAPT | |
| SCHEMBL3381299 | 0.82 | CYP1A2 (0.57) | CYP1A2CYP3A4CYP2C19KDM4EMAPT | |
| SCHEMBL3639386 | 0.82 | CYP1A2 (0.57) | CYP1A2CYP3A4CYP2C19ADRA2ACLCN2 | |
| SCHEMBL3639755 | 0.80 | CYP1A2 (0.41) | CYP1A2CYP3A4CYP2C19ADRA2ACLCN2 | |
| SCHEMBL3226447 | 0.77 | KRAS (0.51) | CYP1A2CYP3A4CYP2C19ADRA2ACLCN2 | |
| SCHEMBL3383227 | 0.77 | MAPT (0.55) | KDM4EMAPTMEN1GAAKMT2A | |
| SCHEMBL13493974 | 0.75 | CYP1A2 (0.44) | CYP1A2CYP3A4CYP2C19ADRA2ACLCN2 | |
| SCHEMBL4558999 | 0.75 | CYP1A2 (0.77) | CYP1A2CYP3A4CYP2C19ADRA2ACLCN2 | |
| SCHEMBL3638375 | 0.73 | CYP1A2 (0.45) | CYP1A2CYP3A4CYP2C19ADRA2ACLCN2 | |
| SCHEMBL3802469 | 0.73 | KDM4E (0.47) | CYP1A2CYP3A4CYP2C19KDM4EMAPT |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2149551-A1 | N-(indol-3-ylalkyl)-(hetero)arylamid derivatives as modulators of EP2 receptors | Bayer Schering Pharma AG (DE) | 2010-02-03 | — | — | EP | claimed |