Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HRH3 | Q9Y5N1 | 5/20 | 0.36 |
| ▸ | BMPR1B | O00238 | 1/20 | 0.35 |
| ▸ | BMPR1A | P36894 | 1/20 | 0.35 |
| ▸ | TGFBR1 | P36897 | 1/20 | 0.35 |
| ▸ | ACVRL1 | P37023 | 1/20 | 0.35 |
| ▸ | ACVR1 | Q04771 | 1/20 | 0.35 |
| ▸ | HTR3A | P46098 | 1/20 | 0.34 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.33 |
| ▸ | MCHR1 | Q99705 | 1/20 | 0.33 |
| ▸ | GPBAR1 | Q8TDU6 | 2/20 | 0.33 |
| ▸ | MAOA | P21397 | 1/20 | 0.32 |
| ▸ | MAOB | P27338 | 1/20 | 0.32 |
| ▸ | CYP11B1 | P15538 | 1/20 | 0.32 |
| ▸ | CYP11B2 | P19099 | 1/20 | 0.32 |
| ▸ | HRH1 | P35367 | 3/20 | 0.32 |
| ▸ | CCR3 | P51677 | 3/20 | 0.32 |
| ▸ | KCNH2 | Q12809 | 3/20 | 0.32 |
| ▸ | MLNR | O43193 | 1/20 | 0.32 |
| ▸ | EPHX2 | P34913 | 1/20 | 0.31 |
| ▸ | EGFR | P00533 | 1/20 | 0.31 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL3380203 | 0.88 | HRH3 (0.48) | HRH3ACVR1KMT2AMCHR1CYP11B1 | |
| SCHEMBL3376109 | 0.81 | HRH3 (0.40) | HRH3GPBAR1HRH1CCR3KCNH2 | |
| SCHEMBL3379954 | 0.81 | HRH3 (0.40) | HRH3GPBAR1HRH1CCR3KCNH2 | |
| SCHEMBL3377127 | 0.80 | HRH3 (0.40) | HRH3BMPR1BBMPR1ATGFBR1ACVRL1 | |
| SCHEMBL3377130 | 0.80 | HRH3 (0.40) | HRH3BMPR1BBMPR1ATGFBR1ACVRL1 | |
| SCHEMBL3377403 | 0.78 | KMT2A (0.44) | HRH3KMT2AMCHR1KCNH2 | |
| SCHEMBL3381646 | 0.77 | HRH3 (0.49) | HRH3ACVR1KMT2AHRH1CCR3 | |
| SCHEMBL3375675 | 0.77 | HRH3 (0.49) | HRH3ACVR1KMT2AHRH1CCR3 | |
| SCHEMBL3379539 | 0.75 | BMPR1B (0.40) | HRH3BMPR1BBMPR1ATGFBR1ACVRL1 | |
| SCHEMBL3377635 | 0.74 | HRH3 (0.48) | HRH3HRH1CCR3KCNH2MLNR |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1899296-B1 | HISTAMINE-3 RECEPTOR ANTAGONISTS | PFIZER PROD INC (US) | 2010-11-17 | — | — | EP | claimed |