SCHEMBL338177

SCHEMBL338177

BrCc1cccc(CBr)c1CBr

nearest known ligand 0.38

Predicted protein targets (top 5)

geneUniProtsupporting neighboursconfidence
GABRA1 P14867 3/20 0.38
GABRB2 P47870 3/20 0.38
TRPA1 O75762 1/20 0.36
ALDH1A1 P00352 1/20 0.36
TSHR P16473 1/20 0.36

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL1048652 0.87 ALDH1A1 (0.33) GABRA1GABRB2ALDH1A1TSHR
SCHEMBL18436948 0.87 GABRA1 (0.31) GABRA1GABRB2
SCHEMBL29466647 0.84 TAAR1 (0.38) GABRA1GABRB2TRPA1ALDH1A1TSHR
SCHEMBL629949 0.84 TAAR1 (0.38) GABRA1GABRB2TRPA1ALDH1A1TSHR
SCHEMBL4828640 0.82 GABRA1 (0.35) GABRA1GABRB2TRPA1ALDH1A1TSHR
SCHEMBL1294517 0.82 TAAR1 (0.43) ALDH1A1
SCHEMBL31057408 0.82 TAAR1 (0.37) GABRA1GABRB2
SCHEMBL3871871 0.82 TAAR1 (0.37) GABRA1GABRB2
SCHEMBL3304485 0.82 TAAR1 (0.38) GABRA1GABRB2ALDH1A1TSHR
SCHEMBL4455672 0.82 GABRA1 (0.31) GABRA1GABRB2

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 881 patents — showing the first 20. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
US-11912794-B2 Modulation of structured polypeptide specificity Bicyclerd Limited (GB) 2024-02-27 US claimed
WO-2023229390-A1 METHOD FOR MANUFACTURING THIN-FILM COMPOSITE MEMBRANE FOR WATER TREATMENT, HAVING EXTREME ACID AND BASE STABILITY 고려대학교 산학협력단 2023-11-30 WO claimed
US-11753444-B2 Modulation of structured polypeptide specificity Bicyclerd Limited (GB) 2023-09-12 US claimed
US-11524989-B2 AML antigens and uses thereof KLING BIOTHERAPEUTICS B.V. (NL) 2022-12-13 US claimed
EP-2474613-B2 Methods and compositions BICYCLERD LTD (GB) 2022-02-16 EP claimed
US-20210207127-A1 LIGANDS AND METHODS OF SELECTING BINDING TARGETS FOR SUCH BICYCLERD (GB) 2021-07-08 US claimed
US-20210122786-A1 MODULATION OF STRUCTURED POLYPEPTIDE SPECIFICITY Bicyclerd Limited (GB) 2021-04-29 US claimed
EP-3803878-A2 LIGANDS AND METHODS OF SELECTING BINDING TARGETS FOR SUCH Bicyclerd Limited (GB) 2021-04-14 EP claimed
CN-112534504-A Ligands and methods of selecting binding targets for the ligands 拜斯科阿迪有限公司 2021-03-19 CN claimed
US-20210079043-A1 MODULATION OF STRUCTURED POLYPEPTIDE SPECIFICITY Bicyclerd Limited (GB) 2021-03-18 US claimed
EP-1844337-A1 BINDING COMPOUNDS, IMMUNOGENIC COMPOUNDS AND PEPTIDOMIMETICS PEPSCAN SYSTEMS B.V. (NL) 2007-10-17 EP claimed
CN-1907929-A Method of continuous and high-yield separating and extracting 1,3-dihydroxypropane from fermentation liquid UNIV EAST CHINA SCIENCE & TECH (CN) 2007-02-07 CN claimed
WO-2006078161-A1 BINDING COMPOUNDS, IMMUNOGENIC COMPOUNDS AND PEPTIDOMIMETICS PEPSCAN SYSTEMS B.V. (NL) 2006-07-27 WO claimed
US-20060073518-A1 Method for selecting a candidate drug compound PEPSCAN SYSTEMS B. V. (NL) 2006-04-06 US claimed
EP-1597585-A2 METHOD FOR SELECTING A CANDIDATE DRUG COMPOUND PEPSCAN SYSTEMS B.V. (NL) 2005-11-23 EP claimed
WO-2004077062-A2 METHOD FOR SELECTING A CANDIDATE DRUG COMPOUND PEPSCAN SYSTEMS B.V. (NL) 2004-09-10 WO claimed
EP-1452868-A2 Method for selecting a candidate drug compound PEPSCAN SYSTEMS B.V. (NL) 2004-09-01 EP claimed
EP-0620500-A2 Resist and pattern formation using the same HITACHI, LTD. (JP) 1994-10-19 EP claimed
US-5208133-A Photosensitive resin composition SONY CORPORATION (JP) 1993-05-04 US claimed
US-5164477-A Preparation of polyoxazolines Kobayashi, Shiro (JP) 1992-11-17 US claimed

Patent text — is the patent's own abstract consistent with the prediction?

For each of this compound's patents that has machine-readable text (2 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.

PatentTitleText reads most aboutPredicted target · text-rank
US-11753444-B2 Modulation of structured polypeptide specificity KLKB1, KLK5, KLK1 GABRA1 3337/4885GABRB2 3494/4885TRPA1 4207/4885
US-20210079043-A1 MODULATION OF STRUCTURED POLYPEPTIDE SPECIFICITY KLKB1, KLK5, KLK1 GABRA1 3337/4885GABRB2 3494/4885TRPA1 4207/4885

“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.