Known targets — ChEMBL curated mechanism
The experimentally established mechanism targets of Rosiglitazone. The predicted profile below is derived independently by chemical similarity — agreement is a validation signal, a miss is honest.
Predicted protein targets (top 12)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PPARG known ✓ | P37231 | 15/20 | 0.98 |
| ▸ | RXRA | P19793 | 2/20 | 0.86 |
| ▸ | RARG | P13631 | 1/20 | 0.86 |
| ▸ | PPARA | Q07869 | 2/20 | 0.61 |
| ▸ | FFAR1 | O14842 | 4/20 | 0.53 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.53 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.53 |
| ▸ | MAPT | P10636 | 1/20 | 0.53 |
| ▸ | PKM | P14618 | 1/20 | 0.53 |
| ▸ | HTT | P42858 | 1/20 | 0.53 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.51 |
| ▸ | ESR1 | P03372 | 1/20 | 0.51 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| Rosiglitazone SCHEMBL11957687 | 0.99 | PPARG (1.00) | PPARGRXRARARGPPARAFFAR1 | |
| Rosiglitazone SCHEMBL5169 | 0.99 | PPARG (1.00) | PPARGRXRARARGPPARAFFAR1 | |
| Rosiglitazone SCHEMBL2355017 | 0.99 | PPARG (1.00) | PPARGRXRARARGPPARAFFAR1 | |
| Rosiglitazone SCHEMBL7052472 | 0.99 | PPARG (1.00) | PPARGRXRARARGPPARAFFAR1 | |
| Rosiglitazone SCHEMBL29530259 | 0.99 | PPARG (1.00) | PPARGRXRARARGPPARAFFAR1 | |
| Rosiglitazone SCHEMBL1489117 | 0.98 | PPARG (0.98) | PPARGRXRARARGPPARAFFAR1 | |
| Rosiglitazone SCHEMBL3375739 | 0.98 | PPARG (0.98) | PPARGRXRARARGPPARAFFAR1 | |
| Rosiglitazone SCHEMBL3377103 | 0.98 | PPARG (0.98) | PPARGRXRARARGPPARAFFAR1 | |
| Rosiglitazone SCHEMBL5468691 | 0.98 | PPARG (0.98) | PPARGRXRARARGPPARAFFAR1 | |
| Rosiglitazone SCHEMBL6976956 | 0.98 | PPARG (0.98) | PPARGRXRARARGPPARAFFAR1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 28 patents — showing the first 20. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1867343-A2 | Novel compounds | GLAXO GROUP LIMITED (GB) | 2007-12-19 | — | — | EP | claimed |
| EP-1325000-B1 | A THIAZOLIDINEDIONE DERIVATIVE AND ITS USE AS ANTIDIABETIC | SMITHKLINE BEECHAM PLC (GB) | 2007-07-25 | — | — | EP | claimed |
| EP-1795531-A1 | A thiazolidinedione derivative and its use as antidiabetic | SMITHKLINE BEECHAM PLC (GB) | 2007-06-13 | — | — | EP | claimed |
| US-20060094691-A1 | Inclusion complexes of rosiglitazone | GLAXO GROUP LIMITED (GB) | 2006-05-04 | — | — | US | claimed |
| EP-1509249-A2 | INCLUSION COMPLEXES OF ROSIGLITAZONE | GLAXO GROUP LIMITED (GB) | 2005-03-02 | — | — | EP | claimed |
| US-20040038968-A1 | Thiazolidinedione derivative and its use as antidiabetic | SMITHKLINE BEECHAM P.L.C. (GB) | 2004-02-26 | — | — | US | claimed |
| WO-2003099337-A2 | INCLUSION COMPLEXES OF ROSIGLITAZONE | GLAXO GROUP LIMITED (GB) | 2003-12-04 | — | — | WO | claimed |
| EP-1325000-A1 | A THIAZOLIDINEDIONE DERIVATIVE AND ITS USE AS ANTIDIABETIC | SMITHKLINE BEECHAM PLC (GB) | 2003-07-09 | — | — | EP | claimed |
| WO-2002026736-A1 | A THIAZOLIDINEDIONE DERIVATIVE AND ITS USE AS ANTIDIABETIC | SMITHKLINE BEECHAM P.L.C. (GB) | 2002-04-04 | — | — | WO | claimed |
| CN-101961333-A | A thiazolidinedione derivative and its use as antidiabetic | SMITHKLINE BEECHAM PLC | 2011-02-02 | — | — | CN | disclosed |
| CN-1620453-B | Thiazolidinedione derivatives and their use as antidiabetics | SMITHKLINE BEECHAM PLC | 2010-12-08 | — | — | CN | disclosed |
| WO-2010067136-A1 | NOVEL CRYSTALLINE FORMS | RICHTER GEDEON NYRT. (HU) | 2010-06-17 | — | — | WO | disclosed |
| WO-2010067136-A1 | NOVEL CRYSTALLINE FORMS | RICHTER GEDEON NYRT. (HU) | 2010-06-17 | — | — | WO | disclosed |
| EP-1867343-A2 | Novel compounds | GLAXO GROUP LIMITED (GB) | 2007-12-19 | — | — | EP | disclosed |
| US-20040038968-A1 | Thiazolidinedione derivative and its use as antidiabetic | SMITHKLINE BEECHAM P.L.C. (GB) | 2004-02-26 | — | — | US | disclosed |
| WO-2003099337-A2 | INCLUSION COMPLEXES OF ROSIGLITAZONE | GLAXO GROUP LIMITED (GB) | 2003-12-04 | — | — | WO | disclosed |
| EP-1325000-A1 | A THIAZOLIDINEDIONE DERIVATIVE AND ITS USE AS ANTIDIABETIC | SMITHKLINE BEECHAM PLC (GB) | 2003-07-09 | — | — | EP | disclosed |
| EP-1242418-A1 | ANTIDIABETIC THIAZOLIDINEDIONES AND THEIR PREPARATION | RICHTER GEDEON VEGYESZETI GYAR R.T. (HU) | 2002-09-25 | — | — | EP | disclosed |
| WO-2002026736-A1 | A THIAZOLIDINEDIONE DERIVATIVE AND ITS USE AS ANTIDIABETIC | SMITHKLINE BEECHAM P.L.C. (GB) | 2002-04-04 | — | — | WO | disclosed |
| WO-2001044240-A1 | ANTIDIABETIC THIAZOLIDINEDIONES AND THEIR PREPARATION | Richter Gedeon Vegyészeti Gyár Rt. (HU) | 2001-06-21 | — | — | WO | disclosed |