Predicted protein targets (top 10)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KDR | P35968 | 9/20 | 0.38 |
| ▸ | FGFR3 | P22607 | 5/20 | 0.37 |
| ▸ | ROCK2 | O75116 | 2/20 | 0.35 |
| ▸ | WNT1 | P04628 | 2/20 | 0.35 |
| ▸ | GSK3B | P49841 | 2/20 | 0.35 |
| ▸ | DYRK1A | Q13627 | 2/20 | 0.35 |
| ▸ | FLT3 | P36888 | 2/20 | 0.34 |
| ▸ | BDKRB1 | P46663 | 1/20 | 0.34 |
| ▸ | ROCK1 | Q13464 | 2/20 | 0.34 |
| ▸ | RET | P07949 | 1/20 | 0.33 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL3385167 | 0.91 | KDR (0.39) | KDRFGFR3WNT1GSK3BDYRK1A | |
| SCHEMBL3186574 | 0.90 | KDR (0.39) | KDRFGFR3ROCK2WNT1GSK3B | |
| SCHEMBL3177651 | 0.88 | KDR (0.39) | KDRFGFR3FLT3 | |
| SCHEMBL3386462 | 0.82 | KDR (0.39) | KDRFGFR3FLT3 | |
| SCHEMBL3384404 | 0.81 | KDR (0.42) | KDRFGFR3FLT3ROCK1 | |
| SCHEMBL3202028 | 0.81 | KDR (0.41) | KDRFGFR3WNT1GSK3BDYRK1A | |
| SCHEMBL3379613 | 0.81 | KDR (0.37) | KDRFGFR3WNT1GSK3BDYRK1A | |
| SCHEMBL3386379 | 0.81 | FGFR3 (0.42) | KDRFGFR3 | |
| SCHEMBL3386457 | 0.79 | DDR1 (0.42) | KDRFGFR3BDKRB1RET | |
| SCHEMBL4973341 | 0.79 | FGFR3 (0.42) | KDRFGFR3 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-101128461-B | Imidazo (1, 2-a) pyridine compounds as VEGF-R2 inhibitors | LILLY CO ELI | 2010-12-22 | — | — | CN | disclosed |
| EP-1904494-B1 | IMIDAZO[1,2-A]PYRIDINE COMPOUNDS AS VEGF-R2 INHIBITORS | LILLY CO ELI (US) | 2010-12-01 | — | — | EP | disclosed |
| CN-101128461-A | Imidazo (1, 2-a) pyridine compounds as VEGF-R2 inhibitors | LILLY CO ELI (US) | 2008-02-20 | — | — | CN | disclosed |