Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KDR | P35968 | 10/20 | 0.39 |
| ▸ | FGFR3 | P22607 | 8/20 | 0.39 |
| ▸ | MOK | Q9UQ07 | 1/20 | 0.36 |
| ▸ | BDKRB1 | P46663 | 1/20 | 0.34 |
| ▸ | MAPK14 | Q16539 | 1/20 | 0.34 |
| ▸ | SMO | Q99835 | 1/20 | 0.34 |
| ▸ | WNT1 | P04628 | 1/20 | 0.34 |
| ▸ | GSK3B | P49841 | 1/20 | 0.34 |
| ▸ | DYRK1A | Q13627 | 1/20 | 0.34 |
| ▸ | NPC1 | O15118 | 1/20 | 0.34 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.34 |
| ▸ | TSHR | P16473 | 1/20 | 0.34 |
| ▸ | CLK1 | P49759 | 1/20 | 0.34 |
| ▸ | RAB9A | P51151 | 1/20 | 0.34 |
| ▸ | JAK2 | O60674 | 1/20 | 0.34 |
| ▸ | JAK1 | P23458 | 1/20 | 0.34 |
| ▸ | TYK2 | P29597 | 1/20 | 0.34 |
| ▸ | JAK3 | P52333 | 1/20 | 0.34 |
| ▸ | EPHX2 | P34913 | 1/20 | 0.34 |
| ▸ | PDGFRA | P16234 | 1/20 | 0.33 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL3382115 | 0.91 | KDR (0.38) | KDRFGFR3BDKRB1WNT1GSK3B | |
| SCHEMBL3386379 | 0.90 | FGFR3 (0.42) | KDRFGFR3MOKMAPK14SMO | |
| SCHEMBL4973341 | 0.89 | FGFR3 (0.42) | KDRFGFR3RAB9A | |
| SCHEMBL3187730 | 0.88 | KDR (0.41) | KDRFGFR3RAB9A | |
| SCHEMBL3386227 | 0.81 | KDR (0.43) | KDRFGFR3MOKBDKRB1 | |
| SCHEMBL3186574 | 0.81 | KDR (0.39) | KDRFGFR3WNT1GSK3BDYRK1A | |
| SCHEMBL3383557 | 0.80 | KDR (0.44) | KDRFGFR3 | |
| SCHEMBL3385390 | 0.79 | KDR (0.49) | KDRFGFR3 | |
| SCHEMBL3384206 | 0.78 | KDR (0.45) | KDRFGFR3RAB9A | |
| SCHEMBL3385425 | 0.78 | KDR (0.44) | KDRFGFR3 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1904494-B1 | IMIDAZO[1,2-A]PYRIDINE COMPOUNDS AS VEGF-R2 INHIBITORS | LILLY CO ELI (US) | 2010-12-01 | — | — | EP | disclosed |