Predicted protein targets (top 11)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | RET | P07949 | 10/20 | 0.50 |
| ▸ | NTRK1 | P04629 | 2/20 | 0.49 |
| ▸ | MAPK14 | Q16539 | 8/20 | 0.47 |
| ▸ | ERBB2 | P04626 | 1/20 | 0.45 |
| ▸ | MAPK11 | Q15759 | 1/20 | 0.45 |
| ▸ | AURKA | O14965 | 1/20 | 0.43 |
| ▸ | MAP4K4 | O95819 | 1/20 | 0.43 |
| ▸ | CSF1R | P07333 | 1/20 | 0.43 |
| ▸ | NTRK3 | Q16288 | 1/20 | 0.43 |
| ▸ | NTRK2 | Q16620 | 1/20 | 0.43 |
| ▸ | AURKB | Q96GD4 | 1/20 | 0.43 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL21436554 | 0.83 | MAPK14 (0.49) | MAPK14MAPK11 | |
| SCHEMBL1256126 | 0.80 | ALDH1A1 (0.46) | RETMAPK14 | |
| SCHEMBL16537069 | 0.77 | RET (0.53) | RET | |
| SCHEMBL31391223 | 0.76 | MAPK14 (0.53) | MAPK14MAPK11 | |
| SCHEMBL1257268 | 0.76 | FLT3 (0.54) | RETNTRK1CSF1R | |
| SCHEMBL3478663 | 0.76 | CDK8 (0.51) | MAPK14MAPK11 | |
| SCHEMBL3380812 | 0.73 | ALDH1A1 (0.65) | — | |
| SCHEMBL13200504 | 0.72 | MAPK14 (0.70) | RETNTRK1MAPK14 | |
| SCHEMBL3383205 | 0.72 | CCNE1 (0.46) | — | |
| SCHEMBL23170036 | 0.72 | RET (0.49) | RETMAPK14 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1904494-B1 | IMIDAZO[1,2-A]PYRIDINE COMPOUNDS AS VEGF-R2 INHIBITORS | LILLY CO ELI (US) | 2010-12-01 | — | — | EP | disclosed |