Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CCNE1 | P24864 | 12/20 | 0.46 |
| ▸ | CDK2 | P24941 | 12/20 | 0.46 |
| ▸ | CDK5 | Q00535 | 8/20 | 0.46 |
| ▸ | CCNE2 | O96020 | 4/20 | 0.45 |
| ▸ | ALDH1A1 | P00352 | 4/20 | 0.43 |
| ▸ | SMN1; SMN2 | Q16637 | 3/20 | 0.43 |
| ▸ | RAB9A | P51151 | 3/20 | 0.43 |
| ▸ | MEN1 | O00255 | 2/20 | 0.43 |
| ▸ | NPC1 | O15118 | 2/20 | 0.43 |
| ▸ | LMNA | P02545 | 2/20 | 0.43 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.43 |
| ▸ | CDK1 | P06493 | 3/20 | 0.42 |
| ▸ | CDK4 | P11802 | 3/20 | 0.42 |
| ▸ | CCNB1 | P14635 | 3/20 | 0.42 |
| ▸ | CCND1 | P24385 | 3/20 | 0.42 |
| ▸ | CCNT1 | O60563 | 1/20 | 0.42 |
| ▸ | CCNA2 | P20248 | 1/20 | 0.42 |
| ▸ | CDK7 | P50613 | 1/20 | 0.42 |
| ▸ | CDK9 | P50750 | 1/20 | 0.42 |
| ▸ | CCNH | P51946 | 1/20 | 0.42 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL3382498 | 0.84 | ROCK1 (0.46) | CCNE1CDK2CDK5CCNE2ALDH1A1 | |
| SCHEMBL3380812 | 0.82 | ALDH1A1 (0.65) | ALDH1A1SMN1; SMN2RAB9AMEN1NPC1 | |
| SCHEMBL1257268 | 0.74 | FLT3 (0.54) | RAB9ANPC1 | |
| SCHEMBL1256126 | 0.73 | ALDH1A1 (0.46) | ALDH1A1KMT2ADGAT1 | |
| SCHEMBL3382233 | 0.72 | RET (0.50) | — | |
| SCHEMBL30690785 | 0.72 | LIPG (0.53) | — | |
| SCHEMBL6862380 | 0.72 | EPHX2 (0.58) | ALDH1A1SMN1; SMN2RAB9AMEN1NPC1 | |
| SCHEMBL19349384 | 0.70 | CXCR2 (0.43) | ALDH1A1SMN1; SMN2DGAT1 | |
| SCHEMBL15416384 | 0.70 | GAA (0.64) | ALDH1A1SMN1; SMN2MEN1KMT2AHDAC1 | |
| SCHEMBL19261385 | 0.70 | CCND3 (0.43) | CCNE1CDK2CCNE2SMN1; SMN2RAB9A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1904494-B1 | IMIDAZO[1,2-A]PYRIDINE COMPOUNDS AS VEGF-R2 INHIBITORS | LILLY CO ELI (US) | 2010-12-01 | — | — | EP | disclosed |